DOCTORAL THESES
“Hepatoencephalopathy due to mutations in GFM1: obtaining a genetically modified mouse model and preclinical study of gene therapy with adeno-associated vectors”, PhD Program in Biochemistry, Molecular Biology and Biomedicine, Universitat Autònoma de Barcelona.
(Collaborative Project Catalonia: DRUG4-COXPD1).
“MNK inhibition as a therapeutic approach for tumor sensitization to approved therapies” (in progress)
(Collaborative Project Catalonia: MnkImmunOnco)
“Search for new therapeutic options in pediatric osteosarcoma using patient derived tumor cell lines”. Doctoral thesis started on September 1, 2023 which includes the characterization of pre-selected compounds in the screenings.
(Collaborative Project Catalonia: OsteoMetTherapy)
“Use of siRNA as a new therapy for glioblastoma”.
“Advanced therapies for prostate cancer”.
“In-Depth Characterization of Extracellular Vesicles for Their Use as Disease Biomarkers and Next-Generation Nanovectors“
(Collaborative Project Catalonia: EVBRAINTARGET)
“Targeting the MNK/eIF4E axis in the tumor environment“
(Collaborative Project Catalonia: MnkImmunOnco)
“Analysis and validation of materials intended for the design of tissue engineered vascular grafts.”
Doctoral thesis on structural and functional study of MeCP2 and evaluation of compounds that modulate its function.
Doctoral thesis on structural and functional study of BFT-3 and evaluation of compounds that modulate its function.
2023
Daniel Sandín García , Javier Valle , Jordi Gómez , Laura Comas , Maria Nieves Larrosa , Maria Nieves Larrosa , Juan José González , María Ángeles Jiménez , Daniel Sandín García , Javier Valle , Jordi Gómez , Laura Comas , Maria Nieves Larrosa , Juan José González , María Ángeles Jiménez , David Andreu and Marc Torrent (2023), Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria. bioRxiv, 2023.10.19.563059
DOI: 10.1101/2023.10.19.563059.
URL: https://www.biorxiv.org/content/10.1101/2023.10.19.563059v1
Durán-Rey, D; Brito-Pereira, R; Ribeiro, C; Ribeiro, S; Sánchez-Margallo, JA; Crisóstomo, V; Irastorza, I; Silván, U; Lanceros-Méndez, S; Sánchez-Margallo, FM. Development of Silk Fibroin Scaffolds for Vascular Repair. Biomacromolecules. 2023 (IF: 6.979; Q1).
DOI: https://doi.org/10.3390/biom13091389
URL: https://www.mdpi.com/2480072
Gallart-Palau X, Lorca C, Mulet M, Sánchez Milán JA, Lisa J, Ngan SC, Iyappan R, Katoueezadeh M, Serra A, Sze SK. Differential systemic decellularization in vivo to study molecular changes in each vasculature layer in murine models of disease. STAR Protoc. 2023 Aug 24;4(3):102524
DOI: 10.1016/j.xpro.2023.102524.
URL: https://www.sciencedirect.com/science/article/pii/S2666166723004914
Gallego-Yerga, L.; Ceña, V. and Peláez, R.Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents. Pharmaceutics 15: 1698
DOI: 10.3390/pharmaceutics15061698
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/37376146/
Gil-Redondo R., Conde R., Bruzzone C., Seco ML, Bizkarguenaga, M, González-Valle B, de Diego A., Laín A., Habisch H., Haudum C., Verheyen N., Obermayer-Pietsch B., Margarita S., Pelusi S., Verde I., Oliveira N., Sousa A., Zabala-Letona A., Santos-Martin A., Loizaga-Iriarte A., Unda-Urzaiz M., Kazenwadel J., Berezhnoy G., Geisler T., Gawaz M., Cannet C., Schäfer H., Diercks T., Trautwein C., Carracedo A., Madl T., Valenti L., Spraul M., C Lu S. Embade N., Mato J.M., Millet O., The Lancet (Preprint), MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics.
URL: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4625798
Gómez, Jordi and Torrent, Marc, Structural assembly of the bacterial essential interactome. bioRxiv, 2023.06.14.544900
DOI: 10.1101/2023.06.14.544900
URL: https://www.biorxiv.org/content/10.1101/2023.06.14.544900v1.full
Grau, S; Vela, JM; Gurt, A; Barceló-Vidal, J; Ojeda, F; López, I; Gómez-García, L; Loza, MI; Martín-García, E; Maldonado, R; Monfort, J. Efficacy of SIGMAR1-based therapy in the early treatment of confirmed mild symptomatic COVID-19 patients. Journal of Infection.
DOI: 10.1016/j.jinf.2023.11.008
URL: https://www.journalofinfection.com/article/S0163-4453(23)00562-5/fulltext
Liu, Xi; Jimenez-Alesanco, Ana; Zexian, Li; Neira, Jose Luis; Peng, Ling; Rizzuti, Bruno; Chuluyan, Eduardo; Velazquez-Campoy, Adrian; Xia, Yi; Abian, Olga; Santofimia-Castaño, Patricia; Iovanna, Juan (2023). Development of an Efficient and Safe NUPR1 Inhibitor with Anticancer Activity.
LORENZO-LOZANO, M.C.; BLÁZQUEZ-MANZANERA, A.L. and CARNICERO, J.A. How kidney clock works: circadian pattern of eGFR based on a population data group. J Physiol Biochem 79: 543-554 .2023.
DOI: 10.1007/s13105-023-00948-2.
Ortega-Alarcon, David; Claveria-Gimeno, Rafael; Vega, Sonia; Kalani, Ladan; Jorge-Torres, Olga C.; Esteller, Manel; Ausio, Juan; Abian, Olga; Velazquez-Campoy, Adrian (2023) Extending MeCP2 interactome: Canonical nucleosomal histones interact with MeCP2. Nucleic Acids Research.
DOI: 10.1093/nar/gkae051
URL: https://academic.oup.com/nar/article/52/7/3636/7600452
RAKSHIT, S.; MALDONADO, A.; LEZAMA, L.; COHEN, B. and DOUHAL, A. The Effects of Mono – and Bivalent Linear Alkyl Interlayer Spacers on the Photobehavior of Mn (II)-Based Perovskites. Int. J. Mol. Sci. 24: 3280. 2023.
DOI: 10.3390/ijms24043280.
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9967457/
Roy R, Lorca C, Mulet M, Sánchez Milán JA, Baratas A, de la Casa M, Espinet C, Serra A, Gallart-Palau X. Altered ureide protein modification profiles in seminal plasma extracellular vesicles of non-normozoospermic men. Front Endocrinol. 2023 Mar 22;14:1113824
DOI: 10.3389/fendo.2023.1113824.DOI
URL: https://www.frontiersin.org/articles/10.3389/fendo.2023.1113824/full
Sánchez Milán JA, Fernández-Rhodes M, Guo X, Mulet M, Ngan SC, Iyappan R, Katoueezadeh M, Sze SK, Serra A, Gallart-Palau X. Trioxidized cysteine in the aging proteome mimics the structural dynamics and interactome of phosphorylated serine. Aging Cell. 2023 Dec 18:e14062. doi: 10.1111/acel.14062.
URL: acel.14062.
Sandín García D., , Valle Javier, Gómez Jordi, Comas Laura, Larrosa Maria Nieves, González Juan José, Jiménez María Ángeles, Andreu David and Torrent Marc (2023), Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria. bioRxiv, 2023.10.19.563059
DOI: 10.1101/2023.10.19.563059.
URL: https://www.biorxiv.org/content/10.1101/2023.10.19.563059v1
2022
De la Torre, C; Játiva, P; Posadas, I; Manzaranres, D; Jiménez, J.L; Ortiz, C; Fernández, J.M, and Ceña, V., A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells. Pharmaceutics 14: 2424. 2022.
DOI: 10.3390/pharmaceutics14112424.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/36365241/.
Durán-Rey, D; Brito-Pereira, R; Ribeiro, C; Ribeiro, S; Sánchez-Margallo, JA; Crisóstomo, V; Irastorza, I; Silván, U; Lanceros-Méndez, S; Sánchez-Margallo, FM. Development and evaluation of different electroactive poly(vinylidene fluoride) architectures for endothelial cell culture. Frontiers in Bioengineering and Biotechnology. 2022 (IF: 6.064; Q1).
DOI: https://doi.org/10.3389/fbioe.2022.1044667
URL: https://www.frontiersin.org/articles/10.3389/fbioe.2022.1044667/full
PEREZ-CARRIÓN, M.D.; POSADAS, I.; SOLERA, J. and CEÑA, V. LRRK2 and Proteostasis in Parkinson’s Disease. Int. J. Mol. Sci. 23: 6808. 2022.
DOI: 10.3390/ijms23126808.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35743250/
POSADAS, I.; ROMERO-CASTILLO, L.; RONCA, R.A.; KARPUS, A.; MIGNANI, S.; MAJORAL, J.P.; MUÑOZ-FERNÁNDEZ, M.A. and CEÑA, V. Engineered Neutral Phosphorous Dendrimers Protect Mouse Cortical Neurons and Brain Organoids from Excitotoxic Death. Int.J. Mol. Sci. 23: 4391. 2022.
DOI: 10.3390/ijms23084391.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024777/.
SAROWAR, S.; CIRILLO, D.; JÁTIVA, P.; NILSEN, M.H.; OTRAGANE, S.A.; HEGGDAL, J.; SELHEIM, F.; CEÑA, V.; BJØRSVIK, H.R. and ENGER, P. Ø. The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis . Front. Oncol. 12: 786739. 2022.
DOI: 10.3389/fonc.2022.786739.
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8858948/
