{"id":14785,"date":"2024-07-03T12:21:15","date_gmt":"2024-07-03T12:21:15","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=14785"},"modified":"2026-02-03T18:35:05","modified_gmt":"2026-02-03T18:35:05","slug":"screentech-screenlcor","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/gl\/screentech-screenlcor\/","title":{"rendered":"ScreenTech-ScreenLCOR"},"content":{"rendered":"\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-cover alignfull is-light wp-duotone-unset-1\" style=\"margin-top:0;padding-top:48px;padding-right:48px;padding-bottom:48px;padding-left:48px;min-height:430px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-30 has-background-dim\" style=\"background-color:#8d99bd\"><\/span><img fetchpriority=\"high\" decoding=\"async\" width=\"395\" height=\"395\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge5.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"\" data-object-fit=\"cover\" data-object-position=\"36% 72%\" style=\"object-position:36% 72%;\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge5.jpg 395w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge5-300x300.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge5-150x150.jpg 150w\" sizes=\"(max-width: 395px) 100vw, 395px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-0b562c1c wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-left has-white-color has-text-color\" style=\"font-size:81px;font-style:normal;font-weight:700;letter-spacing:0px;line-height:1;text-transform:uppercase\">SCREENTECH<br>ScreenLCOR <\/h2>\n<\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Identificaci\u00f3n de peque\u00f1as mol\u00e9culas que modulan la expresi\u00f3n de LCOR para sensibilizar las c\u00e9lulas de c\u00e1ncer de mama a los inhibidores de puntos de control inmunitarios<p><\/p><\/h2>\n\n\n\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>L\u00cdNEA DE ACTUACI\u00d3N 3<\/strong>: PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS DE INTERACCIONES F\u00c1RMACO-DIANA<br><br><strong>Palabras clave:<\/strong> C\u00e1ncer de mama, met\u00e1stasis, LCOR, inmunoterapia, cribado de drogas<br><strong>Coordina: <\/strong>Hospital del Mar Research Institute Barcelona<br><strong>Persona de contacto: <\/strong>Dr. Toni Celi\u00e0-Terrassa | acelia@researchmar.net<\/p>\n<\/div>\n<\/div>\n\n\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">RESUMEN PROYECTO<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<p>El c\u00e1ncer de mama metast\u00e1sico no es curable y supone hasta un total de 680.000 muertes\/a\u00f1o. Una terapia potencial para evitar este dram\u00e1tico n\u00famero de muertes es la inmunoterapia basada en inhibidores de puntos de control inmunol\u00f3gico (ICI). Sin embargo, ICI ha mostrado beneficios limitados en estos pacientes. Un mecanismo principal de resistencia a ICI informado en casos cl\u00ednicos es la deficiencia en la presentaci\u00f3n de ant\u00edgenos, que determina la visibilidad del tumor para las c\u00e9lulas inmunes. Hemos descubierto que LCOR es un regulador esencial de la maquinaria de presentaci\u00f3n de ant\u00edgenos (APM) en c\u00e9lulas tumorales y un factor cr\u00edtico para la respuesta a la terapia ICI en el c\u00e1ncer de mama. Hemos obtenido respuestas radicales en el \u00e1mbito precl\u00ednico con ICI en c\u00e1ncer de mama. Obtuvimos una eficacia curativa duradera en m\u00faltiples modelos precl\u00ednicos, explicada por tener actividad terap\u00e9utica en todas las poblaciones de c\u00e9lulas tumorales. Por lo tanto, LCOR emerge como un socio terap\u00e9utico fundamental de ICI para mejorar su eficacia en los c\u00e1nceres de mama metast\u00e1sicos, mediante el aumento de la APM tumoral, haciendo que las c\u00e9lulas de c\u00e1ncer de mama metast\u00e1sico sean visibles y vulnerables a la inmunoterapia. Ahora en este proyecto pretendemos encontrar peque\u00f1as mol\u00e9culas que modulen LCOR y que puedan usarse como agentes terap\u00e9uticos. Patentamos el uso de cualquier tipo de activador LCOR, incluidas las mol\u00e9culas peque\u00f1as, en combinaci\u00f3n con cualquier tipo de terapia ICI. Adem\u00e1s, recientemente se ha presentado una segunda patente que cubre un uso m\u00e1s amplio de esta tecnolog\u00eda (m\u00e1s inmunoterapias o co-tratamientos y m\u00e1s condiciones patol\u00f3gicas). Nuestro objetivo es utilizar mol\u00e9culas peque\u00f1as que modulen la expresi\u00f3n de LCOR y, por tanto, modular la respuesta de la inmunoterapia ICI en c\u00e1nceres de mama.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto ScreenLCOR - Identificar peque\u00f1as mol\u00e9culas para sensibilizar las c\u00e9lulas de c\u00e1ncer de mama\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/TbqU68TV-I4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<\/div><h2 class=\"tabtitle\">RESULTADOS DEL PROYECTO<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"249\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Figure-1024x249.png\" alt=\"\" class=\"wp-image-23055\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Figure-1024x249.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Figure-300x73.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Figure-768x187.png 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Figure.png 1478w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><p>El objetivo de este proyecto es identificar peque\u00f1as mol\u00e9culas que aumenten la expresi\u00f3n de LCOR, una prote\u00edna con relevancia emergente en la biolog\u00eda del c\u00e1ncer de mama y la regulaci\u00f3n inmunitaria. Para lograrlo, hemos dise\u00f1ado una l\u00ednea celular de c\u00e1ncer de mama con un sistema reportero integrado que nos permite monitorizar f\u00e1cilmente los niveles de LCOR dentro de las c\u00e9lulas vivas. Este sistema produce una se\u00f1al luminosa cuando se expresa la prote\u00edna LCOR, lo que permite medir de forma r\u00e1pida y fiable los cambios en los niveles de LCOR.  <\/p>\n\n<p>Utilizando esta l\u00ednea celular informadora optimizada, realizamos un cribado a gran escala de aproximadamente 100 000 compuestos qu\u00edmicos para identificar aquellos capaces de aumentar la expresi\u00f3n de LCOR. La lectura basada en la luz permiti\u00f3 analizar todos los compuestos de manera eficiente y rentable, algo que no habr\u00eda sido posible con enfoques m\u00e1s laboriosos. Al establecer umbrales claros basados en compuestos de control y se\u00f1ales de fondo, pudimos identificar sistem\u00e1ticamente los compuestos que produc\u00edan un aumento significativo de los niveles de LCOR.  <\/p>\n\n<p>Este enfoque de cribado condujo a la identificaci\u00f3n de m\u00e1s de mil compuestos candidatos iniciales, que posteriormente se redujeron mediante pasos de confirmaci\u00f3n adicionales a un conjunto m\u00e1s peque\u00f1o de resultados de alta confianza (&gt;100 resultados). Estos compuestos representan puntos de partida prometedores para futuras investigaciones y proporcionan una base s\u00f3lida para comprender c\u00f3mo se puede modular farmacol\u00f3gicamente la expresi\u00f3n de LCOR.  <\/p><\/p>\n\n\n\n<div class=\"wp-block-file alignwide\"><a id=\"wp-block-file--media-791403b7-365c-4cd8-9dba-8514aa9acdc9\" href=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Resum-ScreenLCOR-ES.pdf\">Descargar ficha resultados<\/a><\/div>\n\n\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"247\" height=\"58\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/imagen-9.png\" alt=\"\" class=\"wp-image-14773\" style=\"width:234px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Identificaci\u00f3n de peque\u00f1as mol\u00e9culas que modulan la expresi\u00f3n de LCOR para sensibilizar las c\u00e9lulas de c\u00e1ncer de mama a los inhibidores de puntos de control inmunitarios.<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> C\u00e1ncer de mama, met\u00e1stasis, LCOR, inmunoterapia, cribado de drogas.<\/p>\n","protected":false},"author":15,"featured_media":14781,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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