{"id":11581,"date":"2024-04-11T07:58:20","date_gmt":"2024-04-11T07:58:20","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=11581"},"modified":"2025-06-12T11:08:16","modified_gmt":"2025-06-12T11:08:16","slug":"fastrack","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/gl\/fastrack\/","title":{"rendered":"FASTRACK"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image alignright size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"498\" height=\"377\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas2.png\" alt=\"\" class=\"wp-image-11572\" style=\"border-radius:7px;width:254px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas2.png 498w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas2-300x227.png 300w\" sizes=\"(max-width: 498px) 100vw, 498px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Interacci\u00f3n nanopart\u00edcula\/f\u00e1rmaco en tiempo real<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 5:<\/strong> DESARROLLO DE NANOF\u00c1RMACOS, BIODISTRIBUCI\u00d3N, TOXICIDAD Y ACCIONES TERAP\u00c9UTICAS EN MODELOS DE PATOLOG\u00cdA<br><br><strong>Palabras clave:<\/strong> Flavonoides, c\u00e1ncer, topotec\u00e1n, tiempo real, nanopart\u00edculas, nanomedicina.<br><strong>Coordina:<\/strong> Universidad de Castilla-La Mancha <br><strong>Persona de contacto:<\/strong> Abderrazzak Douhal (Abderrazzak.Douhal@uclm.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>El objetivo central de este proyecto consiste en estudiar en tiempo real (escala de femtosegundos) la interacci\u00f3n entre flavonoides y topotec\u00e1n con nanopart\u00edculas que puedan ejercer de transportadores de estos f\u00e1rmacos antitumorales incrementando su efectividad, Esto contribuir\u00eda a dise\u00f1ar complejos con nanopart\u00edculas biocompatibles basadas en complejos de iones met\u00e1licos para el posible transporte de f\u00e1rmacos basados en flavonoides y topotec\u00e1n. Los compuestos flavonoides son ampliamente conocidos en la comunidad cient\u00edfica debido a su utilidad multifac\u00e9tica, como propiedades anticancer\u00edgenas, antibacterianas y antivirales. El topotec\u00e1n es un f\u00e1rmaco antitumoral que inhibe la topoisomerasa I de las c\u00e9lulas tumorales interfiriendo con su replicaci\u00f3n. La formulaci\u00f3n en escala nano de este tipo de f\u00e1rmacos est\u00e1 en progreso para mejorar la biocompatibilidad general, la capacidad de control y direccionamiento, as\u00ed como la rentabilidad de los mismos. A trav\u00e9s de este proyecto, nos proponemos dise\u00f1ar complejos de metales tanto con flavonoides como con topotec\u00e1n para mejorar sus propiedades antioxidantes y anticancer\u00edgenas, as\u00ed como nanopart\u00edculas basadas en estos iones met\u00e1licos para estimular a\u00fan m\u00e1s el proceso de transporte dirigido de f\u00e1rmacos dentro de las c\u00e9lulas tumorales, lo cual nunca ha sido considerado entre la comunidad cient\u00edfica. El proyecto pretende contestar a las siguientes preguntas:<\/p>\n\n\n\n<p>\u00bfComo es de robusto un complejo (composito) formado por un medicamento y su nanopart\u00edcula?<\/p>\n\n\n\n<p>\u00bfQu\u00e9 factores o interacciones determinan la estabilidad del complejo?<\/p>\n\n\n\n<p>\u00bfComo podemos liberar el medicamento de la nanopart\u00edcula sin alterar su estructura y eficacia?<\/p>\n\n\n\n<p>\u00a0\u00bfQu\u00e9 efecto tiene la luz (l\u00e1ser) necesaria para las determinaciones en tiempo real sobre la estabilidad del complejo o liberaci\u00f3n del medicamento?<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto FASTRACK -  Interacci\u00f3n f\u00e1rmaco nanoart\u00edculas\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/8imWxCdtJvM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1514\" height=\"381\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm.png\" alt=\"\" class=\"wp-image-9499\" style=\"width:233px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm.png 1514w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm-300x75.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm-1024x258.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm-768x193.png 768w\" sizes=\"(max-width: 1514px) 100vw, 1514px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 5 (LA5)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Interacci\u00f3n nanopart\u00edcula\/f\u00e1rmaco en tiempo real.<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> Flavonoides, c\u00e1ncer, topotec\u00e1n, tiempo real, nanopart\u00edculas, nanomedicina.<\/p>\n","protected":false},"author":15,"featured_media":11576,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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