{"id":11282,"date":"2024-04-08T18:25:52","date_gmt":"2024-04-08T18:25:52","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=11282"},"modified":"2025-06-12T13:57:10","modified_gmt":"2025-06-12T13:57:10","slug":"protecu","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/gl\/protecu\/","title":{"rendered":"PROTECU"},"content":{"rendered":"\n
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Implementaci\u00f3n de tecnolog\u00edas de prote\u00f3mica a nivel de c\u00e9lula \u00fanica con potencial aplicaci\u00f3n en medicina personalizada<\/h2>\n<\/div>\n<\/div>\n\n\n\n
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LINEA DE ACTUACI\u00d3N 2:<\/strong> IMPLEMENTACI\u00d3N Y AN\u00c1LISIS DE BASES DE DATOS EN MEDICINA DE PRECISI\u00d3N.
L\u00ednea de actuaci\u00f3n complementaria: LA4. Desarrollo de modelos biol\u00f3gicos para cribado y estudio de la actividad de mol\u00e9culas terap\u00e9uticas.

Palabras clave:<\/strong> prote\u00f3mica; c\u00e9lula \u00fanica; medicina de precisi\u00f3n; caracterizaci\u00f3n \u00f3mica; bioinform\u00e1tica
Coordina: <\/strong>Instituto de Biomedicina de Sevilla; Consejo Superior de Investigaciones Cient\u00edficas.
Participa:<\/strong> Servicio Andaluz de Salud (Andaluc\u00eda); Hospital Universitario Virgen del Roc\u00edo (Andaluc\u00eda); Universidad de C\u00e1diz (Andaluc\u00eda); Universidad de Sevilla (Andaluc\u00eda).
Persona de contacto: <\/strong>Dr. Alberto Pascual (apascual-ibis@us.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n

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El proyecto de Biotecnolog\u00eda Aplicada a la Salud tiene como foco el desarrollo de tecnolog\u00edas biom\u00e9dicas y bioinform\u00e1ticas que contribuyan a la implantaci\u00f3n efectiva de la Medicina de Precisi\u00f3n, una nueva medicina centrada en el individuo y que har\u00e1 que la diagnosis, tratamiento y prognosis de la enfermedad sea m\u00e1s eficiente en los sistemas de salud espa\u00f1oles. Este es un objetivo muy ambicioso que necesita de m\u00faltiples capacidades tecnol\u00f3gicas y de an\u00e1lisis, as\u00ed como de su implantaci\u00f3n dentro de los sistemas de salud de las CCAA. El origen y el desarrollo de la enfermedad suele estar asociado a tipos celulares especi\u0301ficos, con frecuencia poco abundantes, y a respuestas celulares heteroge\u0301neas (por ejemplo, en el contexto de tumores, a infecci\u00f3n por pato\u0301genos o a sensibilidad a un fa\u0301rmaco). Es por ello que la Medicina de Precisi\u00f3n necesita de una caracterizacio\u0301n o\u0301mica (gen\u00f3mica, transcripto\u0301mica, epigeno\u0301mica, proteo\u0301mica y metabolo\u0301mica) de las muestras biolo\u0301gicas derivadas de pacientes\/controles y biomodelos con resoluci\u00f3n de c\u00e9lula \u00fanica (SC). Estas te\u0301cnicas son capaces de identificar mutaciones soma\u0301ticas asociadas a enfermedad, tipos celulares cri\u0301ticos para la enfermedad, pero poco abundantes, caracterizar poblaciones con diferente sensibilidad a pato\u0301genos, composicio\u0301n de microbiota o drogas, marcadores especi\u0301ficos, asi\u0301 como monitorizar la evolucio\u0301n de una patologi\u0301a u optimizar tratamientos. El objetivo de ese proyecto es desarrollar la potencialidad de la plataforma de \u201csc-proteomics\u201d del Instituto de Biomedicina de Sevilla (IBiS) a partir de muestras humanas de diferente origen (biopsias, piezas quir\u00fargicas, xenoinjertos y avatares derivados de pacientes). A la finalizaci\u00f3n del proyecto, la plataforma tecnol\u00f3gica resultante dispondr\u00e1 de las capacidades cient\u00edfico-t\u00e9cnicas para extender sus servicios a centros de investigaci\u00f3n biom\u00e9dica y hospitalarios que precisen de este tipo de tecnolog\u00eda en estrategias de medicina de precisi\u00f3n.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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COORDINA:<\/p>\n<\/div>\n\n\n\n

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L\u00ednea de actuaci\u00f3n 2 (LA2)<\/i><\/p>\n

<&nbsp>
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Implementaci\u00f3n de tecnolog\u00edas de prote\u00f3mica a nivel de c\u00e9lula \u00fanica con potencial aplicaci\u00f3n en medicina personalizada.\n<\/p>\n

<&nbsp>
\nPalabras clave:<\/strong> prote\u00f3mica; c\u00e9lula \u00fanica; medicina de precisi\u00f3n; caracterizaci\u00f3n \u00f3mica; bioinform\u00e1tica.<\/p>\n","protected":false},"author":15,"featured_media":12237,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[247],"tags":[165,264],"class_list":["post-11282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-gl","tag-analisis-de-datos-gl","tag-andalucia-gl"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts\/11282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/comments?post=11282"}],"version-history":[{"count":4,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts\/11282\/revisions"}],"predecessor-version":[{"id":19774,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts\/11282\/revisions\/19774"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/media\/12237"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/media?parent=11282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/categories?post=11282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/tags?post=11282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}