{"id":11129,"date":"2024-04-08T17:41:28","date_gmt":"2024-04-08T17:41:28","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/ptecu\/"},"modified":"2025-06-13T08:17:25","modified_gmt":"2025-06-13T08:17:25","slug":"ptecu","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/gl\/ptecu\/","title":{"rendered":"PTECU"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"189\" height=\"185\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/and3.png\" alt=\"\" class=\"wp-image-11115\" style=\"width:303px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Plataforma de transcript\u00f3mica Espacial para Aplicaciones Biom\u00e9dicas<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 4:<\/strong> DESARROLLO DE MODELOS BIOL\u00d3GICOS PARA CRIBADO Y ESTUDIO DE LA ACTIVIDAD DE MOL\u00c9CULAS TERAP\u00c9UTICAS<br>L\u00ednea de actuaci\u00f3n complementaria: LA2. Implementaci\u00f3n y an\u00e1lisis de bases de datos en medicina de precisi\u00f3n.<br><br><strong>Palabras clave:<\/strong> transcript\u00f3mica espacial; medicina de precisi\u00f3n; bioinform\u00e1tica; muestras biol\u00f3gicas; gen\u00f3mica de c\u00e9lula individual.<br><strong>Coordina: <\/strong>Instituto de Parasitolog\u00eda y Biomedicina &#8220;L\u00f3pez &#8211; Neyra&#8221;; Consejo Superior de Investigaciones Cient\u00edficas.<br><strong>Participa:<\/strong> Instituto Maim\u00f3nides de investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba; Universidad de Granada; <br><strong>Persona de contacto: <\/strong>Dra. Fuencisla Matesanz del Barrio y Dra. Alicia Barroso del Jesus (direccion.ipbln@csic.es\/abarroso@ipb.csic.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>Los procesos patol\u00f3gicos ocurren en contextos tisulares complejos en los que las interacciones celulares, la influencia del microambiente que rodea las c\u00e9lulas, y la infiltraci\u00f3n y distribuci\u00f3n de c\u00e9lulas inmunes, entre otros factores, juegan papeles protagonistas en la aparici\u00f3n de las alteraciones, la progresi\u00f3n de la enfermedad y la respuesta a los tratamientos. Esto es especialmente trascendente en patolog\u00edas como el c\u00e1ncer, enfermedades neurodegenerativas o enfermedades complejas autoinmunes. La transcript\u00f3mica espacial (spatial transcriptomics, ST) proporciona informaci\u00f3n del perfil transcripcional de las c\u00e9lulas asociada a su localizaci\u00f3n bidimensional en el tejido. Es por ello que la ST aporta un nuevo estrato de informaci\u00f3n molecular fundamental en la investigaci\u00f3n biom\u00e9dica y en su traslaci\u00f3n a la cl\u00ednica. Actualmente, existen tres tecnolog\u00edas principales que permiten abordar este tipo de estudios: GeoMx\u00ae\/nCounter\u00ae (Nanostring), Visium\u00ae (10x Genomics) y Stereo-seq\u00ae (MGI) cada una con sus fortalezas y debilidades. De entre ellas, GeoMx\u00ae\/nCounter\u00ae presenta tres caracter\u00edsticas exclusivas que la convierten en la tecnolog\u00eda de elecci\u00f3n para este proyecto dado su marcado car\u00e1cter cl\u00ednico y traslacional: permite trabajar sobre cualquier muestra parafinada; permite al investigador o profesional de la salud seleccionar zonas espec\u00edficas del tejido, bas\u00e1ndose en las tinciones o marcadores de enfermedad y por \u00faltimo, permite el an\u00e1lisis de un grupo reducido de genes de las zonas espec\u00edficas del tejido (frente al transcriptoma completo). La combinaci\u00f3n de la Single-Cell Sequencing&#8221; (Secuenciaci\u00f3n de C\u00e9lulas Individuales) y la ST constituye una poderosa herramienta para relacionar los fen\u00f3menos patol\u00f3gicos de los tejidos humanos y las alteraciones moleculares constituyendo una de las bases presentes y futuras en las que ha de sustentarse la medicina de precisi\u00f3n.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto PTECU -Plataforma de Transcript\u00f3mica Espacial para Aplicaciones Cl\u00ednicas\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/I4jaTRZVR6w?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"404\" height=\"194\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/05\/neyra.png\" alt=\"\" class=\"wp-image-12187\" style=\"width:142px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/05\/neyra.png 404w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/05\/neyra-300x144.png 300w\" sizes=\"(max-width: 404px) 100vw, 404px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"301\" height=\"55\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/csic-1.png\" alt=\"\" class=\"wp-image-11037\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"310\" height=\"42\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/imibic.png\" alt=\"\" class=\"wp-image-11072\" style=\"width:185px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/imibic.png 310w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/imibic-300x41.png 300w\" sizes=\"(max-width: 310px) 100vw, 310px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"281\" height=\"78\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/unigranada.png\" alt=\"\" class=\"wp-image-11062\" style=\"width:214px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 4 (LA4)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Plataforma de transcript\u00f3mica Espacial para Aplicaciones Biom\u00e9dicas\n<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> transcript\u00f3mica espacial; medicina de precisi\u00f3n; bioinform\u00e1tica; muestras biol\u00f3gicas; gen\u00f3mica de c\u00e9lula individual.<\/p>\n","protected":false},"author":15,"featured_media":11119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[247],"tags":[264,200],"class_list":["post-11129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-gl","tag-andalucia-gl","tag-modelos-biologicos-gl"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts\/11129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/comments?post=11129"}],"version-history":[{"count":5,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts\/11129\/revisions"}],"predecessor-version":[{"id":19836,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/posts\/11129\/revisions\/19836"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/media\/11119"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/media?parent=11129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/categories?post=11129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/tags?post=11129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}