{"id":17570,"date":"2024-11-05T16:05:56","date_gmt":"2024-11-05T16:05:56","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/teses-de-doutoramento\/"},"modified":"2024-11-05T16:11:24","modified_gmt":"2024-11-05T16:11:24","slug":"teses-de-doutoramento","status":"publish","type":"page","link":"https:\/\/planescomplementariossalud.es\/gl\/teses-de-doutoramento\/","title":{"rendered":"teses de doutoramento"},"content":{"rendered":"\t\t
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TESES DE DOUTORAMENTO

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\u201cHepatoencefalopat\u00eda por mutaci\u00f3ns en GFM1: obtenci\u00f3n dun modelo de rato modificado xeneticamente e estudo precl\u00ednico de terapia x\u00e9nica con vectores adeno-asociados\u201d<\/strong> , Programa de Doutoramento en Bioqu\u00edmica, Biolox\u00eda Molecular e Biomedicina da Universidade Aut\u00f3noma de Barcelona.
(Proxecto Colaborativo Catalu\u00f1a: DRUG4-COXPD1)<\/p>\n

“Inhibici\u00f3n de MNK como enfoque terap\u00e9utico para a sensibilizaci\u00f3n tumoral a terapias aprobadas”<\/strong> (en curso)
(Proxecto Colaborativo Catalu\u00f1a: MnkImmunOnco)<\/p>\n

“Busca novas opci\u00f3ns terap\u00e9uticas no osteosarcoma pedi\u00e1trico usando li\u00f1as de c\u00e9lulas tumorais derivadas do paciente”.<\/strong> Tese de doutoramento comezou o 1 de setembro de 2023 que incl\u00fae a caracterizaci\u00f3n de compostos preseleccionados nas proxecci\u00f3ns.
(Proxecto colaborativo de Catalu\u00f1a: OsteoMetTherapy)<\/p>\n

“Uso de siRNA como unha nova terapia para o glioblastoma”<\/strong><\/p>\n

“Terapias avanzadas para o cancro de pr\u00f3stata”<\/strong><\/p>\n

“Caracterizaci\u00f3n en profundidade de ves\u00edculas extracelulares para o seu uso como biomarcadores de enfermidades e nanovectores de pr\u00f3xima xeraci\u00f3n”<\/strong>
(Proxecto Colaborativo Catalu\u00f1a: EVBRAINTARGET)<\/p>\n

“O obxectivo do eixe MNK\/eIF4E no ambiente do tumor”<\/strong>
(Proxecto Colaborativo Catalu\u00f1a: MnkImmunOnco)<\/p>\n

“An\u00e1lise e validaci\u00f3n de materiais destinados ao dese\u00f1o de enxertos vasculares de enxe\u00f1ar\u00eda tisular”<\/strong><\/p>\n

Tese de doutoramento sobre estudo estrutural e funcional de MeCP2 e avaliaci\u00f3n de compostos que modulan a s\u00faa funci\u00f3n<\/p>\n

Tese de doutoramento sobre estudo estrutural e funcional de BFT-3 e avaliaci\u00f3n de compostos que modulan a s\u00faa funci\u00f3n<\/p><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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2023<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Daniel Sand\u00edn Garc\u00eda, Javier Valle, Jordi G\u00f3mez, Laura Comas, Maria Nieves Larrosa, Juan Jos\u00e9 Gonz\u00e1lez, Mar\u00eda \u00c1ngeles Jim\u00e9nez, Daniel Sand\u00edn Garc\u00eda, Javier Valle, Jordi G\u00f3mez, Laura Comas, Maria Nieves Larrosa, Juan Jos\u00e9 Gonz\u00e1lez, Mar\u00eda \u00c1ngeles Jim\u00e9nez, David Andreu e Marc Torrent (2023), Mining the heparinome for cr\u00edptico antimicrobiano p\u00e9ptidos que matan selectivamente bacterias gramnegativas<\/strong> . bioRxiv, 2023.10.19.563059
DOI: 10.1101\/2023.10.19.563059.
Direcci\u00f3n web: https:\/\/www.biorxiv.org\/content\/10.1101\/2023.10.19.563059v1<\/a> <\/p>\n

Dur\u00e1n-Rey, D; Brito-Pereira, R; Ribeiro, C; Ribeiro, S; S\u00e1nchez-Margallo, JA; Cris\u00f3stomo, V; Irastorza, I; Silvan, U; Lanceros-M\u00e9ndez, S; S\u00e1nchez-Margallo, FM. Desenvolvemento de andamios de fibro\u00edna de seda para a reparaci\u00f3n vascular. Biomacromol\u00e9culas. <\/strong> 2023 (IF: 6.979; Q1).
DOI: https:\/\/doi.org\/10.3390\/biom13091389
Direcci\u00f3n web: https:\/\/www.mdpi.com\/2480072<\/a><\/p>\n

Gallart-Palau Descelularizaci\u00f3n sist\u00e9mica diferencial in vivo para estudar cambios moleculares en cada capa vascular en modelos murinos de enfermidades.<\/strong> Protocolo STAR 24 de agosto de 2023;4(3):102524
DOI: 10.1016\/j.xpro.2023.102524.
URL: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2666166723004914<\/a> <\/p>\n

Gallego-Yerga, L.; Ce\u00f1a, V. e Pel\u00e1ez, R. Antimit\u00f3ticos potentes e selectivos a base de benzotiazol con solubilidade en auga mellorada: dese\u00f1o, s\u00edntese e avaliaci\u00f3n como axentes anticancer\u00edxenos novos.<\/strong> Farmac\u00e9utica 15:1698
DOI: 10.3390\/farmac\u00e9utica15061698
Direcci\u00f3n web: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/37376146\/<\/a><\/span><\/p>\n

Gil-Redondo R., Conde R., Bruzzone C., Seco ML, Bizkarguenaga, M, Gonz\u00e1lez-Valle B, de Diego A., La\u00edn A., Habisch H., Haudum C., Verheyen N., Obermayer-Pietsch B., Margarita S., Pelusi S., Verde I., Oliveira N., Sousa A., Zabala-Letona A., Santos-Martin A., Loizaga-Iriarte A., Unda-Urzaiz M., Kazenwadel J. , Berezhnoy G., Geisler T., Gawaz M., Cannet C., Sch\u00e4fer H., Diercks T., Trautwein C., Carracedo A., Madl T., Valenti L., Spraul M., C Lu S. Embade N., Mato JM, Millet O., The Lancet (Preprint), MetSCORE: unha m\u00e9trica molecular para avaliar o risco de s\u00edndrome metab\u00f3lica baseada na metabol\u00f3mica de RMN s\u00e9rica.<\/strong>
URL: https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=4625798 <\/p>\n

G\u00f3mez, Jordi e Torrent, Marc, Ensamblaxe estrutural do interactoma bacteriano esencial.<\/strong> bioRxiv, 2023.06.14.544900
DOI: 10.1101\/2023.06.14.544900
URL: https:\/\/www.biorxiv.org\/content\/10.1101\/2023.06.14.544900v1.full<\/a><\/p>\n

Grau, S; Vela, JM; Gurt, A; Barcel\u00f3-Vidal, J; Ojeda, F; L\u00f3pez, I; G\u00f3mez-Garc\u00eda, L; Loza, MI; Mart\u00edn-Garc\u00eda, E; Maldonado, R; Monfort, J. Eficacia da terapia baseada en SIGMAR1 no tratamento precoz de pacientes con COVID-19 sintom\u00e1ticos leves confirmados.<\/strong> Revista de infecci\u00f3n.
DOI: 10.1016\/j.jinf.2023.11.008
URL: https:\/\/www.journalofinfection.com\/article\/S0163-4453(23)00562-5\/fulltext<\/a><\/p>\n

Liu, Xi; Jim\u00e9nez-Alesanco, Ana; Zexian, Li; Neira, Jose Luis; Peng, Ling; Rizzuti, Bruno; Chuluyan, Eduardo; Vel\u00e1zquez-Campoy, Adri\u00e1n; Xia, Yi; Abian, Olga; Santofimia-Casta\u00f1o, Patricia; Iovanna, Juan. (2023) Desenvolvemento dun inhibidor NUPR1 eficiente e seguro con actividade anticancer\u00edxena.
<\/strong><\/p>\n

LORENZO-LOZANO, MC; BL\u00c1ZQUEZ-MANZANERA, AL e CARNICERO, JA Como funciona o reloxo renal: patr\u00f3n circadiano de eGFR baseado nun grupo de datos de poboaci\u00f3n<\/strong> . J Physiol Biochem 79:543-554.2023.
DOI: 10.1007\/s13105-023-00948-2.<\/p>\n

Ortega-Alarc\u00f3n, David; Claveria-Gimeno, Rafael; Veiga, Sonia; Kalani, Ladan; Jorge-Torres, Olga C.; Esteller, Manel; Ausio, Juan; Abian, Olga; Velazquez-Campoy, Adrian (2023) Extending MeCP2 interactome: Canonical nucleosomal histons interact with MeCP2.<\/strong> Investigaci\u00f3n de \u00c1cidos Nucleicos.
DOI: 10.1093\/nar\/gkae051
URL: https:\/\/academic.oup.com\/nar\/article\/52\/7\/3636\/7600452<\/a><\/p>\n

RAKSHIT, S.; MALDONADO, A.; LEZAMA, L.; COHEN, B. e DOUHAL, A. The Effects of Mono – and Bivalent Lineal Alkyl Interlayer Spacers on the Photobehavior of Mn (II)-Based perovskites<\/strong> . Int. J. Mol. Sci. 24: 3280. 2023.
DOI: 10.3390\/ijms24043280.
Direcci\u00f3n web: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc9967457\/<\/a> <\/p>\n

Roy R, Lorca C, Mulet M, S\u00e1nchez Milan JA, Baratas A, de la Casa M, Espinet C, Serra A, Gallart-Palau X. Altered ureido protein modification profiles in seminal plasma extracellular vesicles of non-normozoospermic men.<\/strong> Endocrinol frontal. 22 de marzo de 2023; 14:1113824
DOI: 10.3389\/fendo.2023.1113824.DOI
URL: https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1113824\/full<\/a> <\/p>\n

S\u00e1nchez Milan JA, Fern\u00e1ndez-Rhodes M, Guo X, Mulet M, Ngan SC, Iyappan R, Katoueezadeh M, Sze SK, Serra A, Gallart-Palau X. A ciste\u00edna trioxidada no proteoma do envellecemento imita a din\u00e1mica estrutural e o interactoma da serina fosforilada. C\u00e9lula envellecida. <\/strong> 18 de decembro de 2023: 14062. doi: 10.1111\/acel.14062.
Direcci\u00f3n URL: acel.14062 <\/p>\n

Sand\u00edn Garc\u00eda D., , Valle Javier, G\u00f3mez Jordi, Comas Laura, Larrosa Maria Nieves, Gonz\u00e1lez Juan Jos\u00e9, Jim\u00e9nez Mar\u00eda \u00c1ngeles, Andreu David e Torrent Marc (2023), Mining the heparinome for cryptic antimicrobial peptides that selectively kill bacteria gram-negative<\/strong> . bioRxiv, 2023.10.19.563059
DOI: 10.1101\/2023.10.19.563059.
Direcci\u00f3n web: https:\/\/www.biorxiv.org\/content\/10.1101\/2023.10.19.563059v1 <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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2022<\/b><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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De la Torre, C; X\u00e1tiva, P; Posadas, I; Manzaranres, D; Jim\u00e9nez, JL; Ortiz, C; Fern\u00e1ndez, JM e Ce\u00f1a, V., Unha nanopart\u00edcula baseada en \u03b2-ciclodextrina cunha eficiencia de transfecci\u00f3n moi alta revela respostas TLR3 activadas por ARNsi en c\u00e9lulas de cancro de pr\u00f3stata humana.<\/strong> Farmac\u00e9utica 14: 2424. 2022.
DOI: 10.3390\/farmac\u00e9utica14112424.
Direcci\u00f3n web: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/36365241\/<\/a> <\/p>\n

Dur\u00e1n-Rey, D; Brito-Pereira, R; Ribeiro, C; Ribeiro, S; S\u00e1nchez-Margallo, JA; Cris\u00f3stomo, V; Irastorza, I; Silvan, U; Lanceros-M\u00e9ndez, S; S\u00e1nchez-Margallo, FM. Desenvolvemento e avaliaci\u00f3n de diferentes arquitecturas electroactivas de poli(fluoruro de vinilideno) para o cultivo de c\u00e9lulas endoteliais<\/strong> . Fronteiras en Bioenxe\u00f1ar\u00eda e Biotecnolox\u00eda. 2022 (IF: 6.064; Q1).
DOI: https:\/\/doi.org\/10.3389\/fbioe.2022.1044667
URL: https:\/\/www.frontiersin.org\/articles\/10.3389\/fbioe.2022.1044667\/full<\/a> <\/p>\n

PEREZ-CARRI\u00d3N, MD; POSADAS, I.; SOLERA, J. e CE\u00d1A, V. LRRK2 and Proteostasis in Parkinson’s Disease.<\/strong> Int. J. Mol. Sci. 23: 6808. 2022.
DOI: 10.3390\/ijms23126808.
URL: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/35743250\/<\/a> <\/p>\n

POSADAS, I.; ROMERO-CASTILLO, L.; RONCA, RA; KARPUS, A.; MIGNANI, S.; MAJORAL, JP; MU\u00d1OZ-FERN\u00c1NDEZ, MA e CE\u00d1A, V. Os dendr\u00edmeros de f\u00f3sforo neutro de enxe\u00f1ar\u00eda protexen as neuronas corticais do rato e os organoides cerebrais da morte excitot\u00f3xica.<\/strong> Int.J. Mol. Sci. 23: 4391. 2022.
DOI: 10.3390\/ijms23084391.
URL: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9024777\/<\/a> <\/p>\n

SAROWAR, S.; CIRILLO, D.; X\u00c1TIVA, P.; NILSEN, MH; OTRAGANE, SA; HEGGDAL, J.; SELHEIM, F.; CE\u00d1A, V.; BJ\u00d8RSVIK, HR e ENGER, P. \u00d8. The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis <\/strong>. Front. Oncol. 12: 786739. 2022.
DOI: 10.3389\/fonc.2022.786739.
URL: http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8858948\/<\/a> <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

TESES DE DOUTORAMENTO \u201cHepatoencefalopat\u00eda por mutaci\u00f3ns en GFM1: obtenci\u00f3n dun modelo de rato modificado xeneticamente e estudo precl\u00ednico de terapia x\u00e9nica con vectores adeno-asociados\u201d , Programa de Doutoramento en Bioqu\u00edmica, Biolox\u00eda Molecular e Biomedicina da Universidade Aut\u00f3noma de Barcelona. (Proxecto Colaborativo Catalu\u00f1a: DRUG4-COXPD1) “Inhibici\u00f3n de MNK como enfoque terap\u00e9utico para a sensibilizaci\u00f3n tumoral a terapias …<\/p>\n

teses de doutoramento<\/span> Ler m\u00e1is »<\/a><\/p>\n","protected":false},"author":15,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-17570","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/pages\/17570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/comments?post=17570"}],"version-history":[{"count":1,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/pages\/17570\/revisions"}],"predecessor-version":[{"id":17571,"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/pages\/17570\/revisions\/17571"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/gl\/wp-json\/wp\/v2\/media?parent=17570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}