{"id":18166,"date":"2024-12-04T13:58:14","date_gmt":"2024-12-04T13:58:14","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=18166"},"modified":"2025-06-16T13:04:58","modified_gmt":"2025-06-16T13:04:58","slug":"nanobrain","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/nanobrain\/","title":{"rendered":"NANOBRAIN"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"583\" height=\"583\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-4.png\" alt=\"\" class=\"wp-image-18170\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-4.png 583w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-4-300x300.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-4-150x150.png 150w\" sizes=\"(max-width: 583px) 100vw, 583px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Desarrollo de nanosistemas para introducir miRNAs en el cerebro a trav\u00e9s de la barrera hematoencef\u00e1lica.<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 5:<\/strong> DESARROLLO DE NANOF\u00c1RMACOS, BIODISTRIBUCI\u00d3N, TOXICIDAD Y ACCIONES TERAP\u00c9UTICAS EN MODELOS DE PATOLOG\u00cdA.<br><br><strong>Palabras clave:<\/strong> Da\u00f1o cerebral, nanotransportadores, barrera hematoencef\u00e1lica, miRNAs.<br><strong>Coordina:<\/strong> Fundaci\u00f3n P\u00fablica Galega de Investigaci\u00f3n Biom\u00e9dica Galicia Sur (FPGIBGS)<br><strong>Participa:<\/strong> Universidad de Vigo (Uvigo) (Galicia); Universidad de Cantabria (Galicia); Instituto de Salud Carlos III (Madrid)<br><strong>Persona de contacto:<\/strong> Carlos Spuch Calvar (Carlos.spuch@iisgaliciasur.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<figure class=\"wp-block-video\"><\/figure>\n\n\n\n<p>Los trastornos cerebrales necesitan tratamientos efectivos, actualmente no tienen, y los pocos que hay son sintomatol\u00f3gicos. Las terapias farmacol\u00f3gicas experimentales que est\u00e1n en desarrollo tienen dificultad de avanzar porque su tama\u00f1o molecular les impide atravesar la barrera hematoencef\u00e1lica (BBB). Menos del 5% de las mol\u00e9culas analizadas pueden pasar a trav\u00e9s de la BBB, el desarrollo de f\u00e1rmacos relacionados con los trastornos relacionados con el cerebro tarda mucho en desarrollarse.<\/p>\n\n\n\n<p>Los nanotransportadores para la administraci\u00f3n de f\u00e1rmacos al cerebro es un m\u00e9todo para transportar mol\u00e9culas con actividad farmacol\u00f3gica a trav\u00e9s de la BBB utilizando nanopart\u00edculas. Una de las v\u00edas actuales que est\u00e1 en desarrollo es la distribuci\u00f3n de f\u00e1rmacos a trav\u00e9s de genes, estos son f\u00e1ciles de introducir en el cerebro, pero solo necesitan de transportadores que puedan introducirlos en la regi\u00f3n adecuada.<\/p>\n\n\n\n<p>Nuestro grupo lleva investigando en el desarrollo de nuevas mol\u00e9culas mediante miRNAs que sean capaces de modular el sistema nervioso central. A partir de exosomas obtuvimos perfiles de miRNAs que modulan la sinaptog\u00e9nesis, neurog\u00e9nesis, axonog\u00e9nesis y gliog\u00e9nesis. A partir de una selecci\u00f3n para escoger los mejores candidatos. Realizaremos un dise\u00f1o de un nanotransportador de SiO2 en 2 capas capaz de introducirse en la BBB y poder liberar 2 tipos de miRNAs de forma secuencial con capacidad de modular el sistema nervioso. Estos nanotransportadores los testaremos en diferentes modelos de la BBB para demostrar su utilidad y funcionamiento in vitro.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto NANOBRAIN - Nanosistemas para introducir miRNAs en el cerebro\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/mJ3PpZzcGGU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"345\" height=\"233\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Galicia-sur.jpg\" alt=\"\" class=\"wp-image-2185\" style=\"width:170px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Galicia-sur.jpg 345w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Galicia-sur-300x203.jpg 300w\" sizes=\"(max-width: 345px) 100vw, 345px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"3543\" height=\"506\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo.png\" alt=\"\" class=\"wp-image-2176\" style=\"width:272px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo.png 3543w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-300x43.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-1024x146.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-768x110.png 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-1536x219.png 1536w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-2048x292.png 2048w\" sizes=\"(max-width: 3543px) 100vw, 3543px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"565\" height=\"353\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-2.png\" alt=\"\" class=\"wp-image-18156\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-2.png 565w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-2-300x187.png 300w\" sizes=\"(max-width: 565px) 100vw, 565px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"567\" height=\"50\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-3.png\" alt=\"\" class=\"wp-image-18161\" style=\"width:431px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-3.png 567w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-3-300x26.png 300w\" sizes=\"(max-width: 567px) 100vw, 567px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 5 (LA5)<\/i><\/p>\n<p><\u00a0><br \/>\n<\/p>\n<p>Desarrollo de nanosistemas para introducir miRNAs en el cerebro a trav\u00e9s de la barrera hematoencef\u00e1lica.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> Da\u00f1o cerebral, nanotransportadores, barrera hematoencef\u00e1lica, miRNAs. <\/p>\n","protected":false},"author":15,"featured_media":18171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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