{"id":14702,"date":"2024-07-03T10:36:52","date_gmt":"2024-07-03T10:36:52","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=14702"},"modified":"2025-06-16T08:25:57","modified_gmt":"2025-06-16T08:25:57","slug":"screentech-imchescreen","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/screentech-imchescreen\/","title":{"rendered":"ScreenTech-ImCheScreen"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"425\" height=\"239\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge3-1.png\" alt=\"\" class=\"wp-image-14697\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge3-1.png 425w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge3-1-300x169.png 300w\" sizes=\"(max-width: 425px) 100vw, 425px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Detecci\u00f3n y selecci\u00f3n de p\u00e9ptidos inhibidores de puntos de control inmunol\u00f3gico multivalentes (ImCheScreen)<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>L\u00cdNEA DE ACTUACI\u00d3N 3:<\/strong> PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS DE INTERACCIONES F\u00c1RMACO-DIANA<br><br><strong>Palabras clave:<\/strong> Quimeras Multivalentes; Prote\u00ednas de Control Inmunitario; Cribado y Clasificaci\u00f3n; Dise\u00f1o de; P\u00e9ptidos; Terapias para el C\u00e1ncer.<br><strong>Coordina: <\/strong>Centre de Regulaci\u00f3 Gen\u00f2mica (CRG)<br><strong>Participa:<\/strong> Centro de Investigaci\u00f3n Cooperativa en Biociencias (CIC biomagune) (Pa\u00eds Vasco)<br><strong>Persona de contacto: <\/strong>Noelia Ferruz | noelia.ferruz@crg.eu<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>Esta propuesta de investigaci\u00f3n esboza un enfoque integral para dise\u00f1ar, expresar, cribar y crear quimeras multivalentes farmacol\u00f3gicas dirigidas a las prote\u00ednas de control inmunitario <em>PD-1<\/em> y <em>CTLA-4<\/em>. Aprovechando las estructuras de rayos X disponibles p\u00fablicamente, nuestro objetivo es dise\u00f1ar fragmentos de uni\u00f3n de novo utilizando modelos de difusi\u00f3n y modelos de lenguaje de prote\u00ednas avanzados para generar una biblioteca de secuencias inhibitorias. Posteriormente, se expresar\u00e1n las prote\u00ednas <em>PD-1, PD-L1, CTLA-4 <\/em>y <em>CD80<\/em> y se marcar\u00e1n con colorantes fluorescentes para ensayos de cribado. El proceso de cribado y clasificaci\u00f3n identificar\u00e1 los candidatos m\u00e1s prometedores, lo que llevar\u00e1 a la creaci\u00f3n de quimeras multivalentes farmacol\u00f3gicas. Las propiedades estructurales se evaluar\u00e1n utilizando un pipeline de filtrado que incluye <em>AlphaFold<\/em>, predicciones de desorden, c\u00e1lculos de \u00e1rea superficial accesible al solvente y din\u00e1mica molecular, seguido de la ensambladura supramolecular posterior de p\u00e9ptidos seleccionados. Este enfoque multidisciplinario promete desarrollar nuevas terapias dirigidas a puntos de control inmunitario para el tratamiento del c\u00e1ncer.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1864\" height=\"904\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/LOGOs-CRG-CAST_2014.jpg\" alt=\"\" class=\"wp-image-9394\" style=\"width:229px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/LOGOs-CRG-CAST_2014.jpg 1864w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/LOGOs-CRG-CAST_2014-300x145.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/LOGOs-CRG-CAST_2014-1024x497.jpg 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/LOGOs-CRG-CAST_2014-768x372.jpg 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/LOGOs-CRG-CAST_2014-1536x745.jpg 1536w\" sizes=\"(max-width: 1864px) 100vw, 1864px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1000\" height=\"409\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/biomagune_v.png\" alt=\"\" class=\"wp-image-19675\" style=\"width:278px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/biomagune_v.png 1000w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/biomagune_v-300x123.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/biomagune_v-768x314.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 3 (LA3)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Detecci\u00f3n y selecci\u00f3n de p\u00e9ptidos inhibidores de puntos de control inmunol\u00f3gico multivalentes (ImCheScreen)<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> Quimeras Multivalentes; Prote\u00ednas de Control Inmunitario; Cribado y Clasificaci\u00f3n; Dise\u00f1o de; P\u00e9ptidos; Terapias para el C\u00e1ncer.<\/p>\n","protected":false},"author":15,"featured_media":14698,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[244],"tags":[195,84,132],"class_list":["post-14702","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-eu","tag-catalunya-eu","tag-cribado-de-farmacos-eu","tag-proyecto-colaborativo-eu"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts\/14702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/comments?post=14702"}],"version-history":[{"count":5,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts\/14702\/revisions"}],"predecessor-version":[{"id":19960,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts\/14702\/revisions\/19960"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/media\/14698"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/media?parent=14702"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/categories?post=14702"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/tags?post=14702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}