{"id":11604,"date":"2024-04-11T10:26:41","date_gmt":"2024-04-11T10:26:41","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=11604"},"modified":"2025-06-12T10:56:12","modified_gmt":"2025-06-12T10:56:12","slug":"nano4glio","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/nano4glio\/","title":{"rendered":"NANO4GLIO"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image alignright size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"959\" height=\"398\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas3.png\" alt=\"\" class=\"wp-image-11598\" style=\"border-radius:7px;width:429px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas3.png 959w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas3-300x125.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cas3-768x319.png 768w\" sizes=\"(max-width: 959px) 100vw, 959px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Nanopart\u00edculas para administrar ARNi a xenoinjertos de glioblastoma derivados de pacientes<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 5:<\/strong> DESARROLLO DE NANOF\u00c1RMACOS, BIODISTRIBUCI\u00d3N, TOXICIDAD Y ACCIONES TERAP\u00c9UTICAS EN MODELOS DE PATOLOG\u00cdA<br>Linea de actuaci\u00f3n complementaria: LA3. Plataforma de cribado de f\u00e1rmacos y an\u00e1lisis interacciones f\u00e1rmaco-diana<br><br><strong>Palabras clave:<\/strong> Glioblastoma, siRNA, nanopart\u00edculas, nanomedicina<br><strong>Coordina:<\/strong> Universidad de Castilla-La Mancha<br><strong>Participa:<\/strong> Universidad de Santiago de Compostela; Universidad de Sevilla<br><strong>Persona de contacto:<\/strong> Valent\u00edn Ce\u00f1a (valentin.cena@gmail.com)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>El principal objetivo de este proyecto es establecer un nuevo enfoque terap\u00e9utico para el glioblastoma (GBM) basado en el uso de tecnolog\u00eda RNAi (m\u00e1s espec\u00edficamente siRNA) para reducir los niveles celulares de prote\u00ednas implicadas en la supervivencia y proliferaci\u00f3n de las c\u00e9lulas tumorales, haci\u00e9ndolas m\u00e1s susceptibles a los f\u00e1rmacos anticancer\u00edgenos y \/o radiaci\u00f3n. El siRNA ser\u00e1 administrado por dos familias diferentes de nanocompuestos multifuncionales de vanguardia que comprenden derivados de \u03b2-ciclodextrina y dihidropiridinas. Los nanocompuestos se modificar\u00e1n en su estructura y superficie qu\u00edmica para realizar de manera eficiente las tareas requeridas para dirigirse a xenoinjertos de GBM intracerebral: cruce de la barrera hematoencef\u00e1lica, direccionamiento a c\u00e9lulas tumorales o im\u00e1genes de tumores. Los siRNA se dise\u00f1ar\u00e1n para desactivar prote\u00ednas clave en las v\u00edas de se\u00f1alizaci\u00f3n implicadas en la proliferaci\u00f3n y supervivencia de c\u00e9lulas GBM, como los complejos Ras\/Raf\/ERK o mTOR. La eficacia de la transfecci\u00f3n de nanocompuestos se probar\u00e1 in vitro en c\u00e9lulas GBM aisladas obtenidas de la disociaci\u00f3n de tumores del paciente de organoides GBM del paciente obtenidos del tejido tumoral resecado durante la cirug\u00eda terap\u00e9utica.<br>Despu\u00e9s de mostrar una alta eficiencia de transfecci\u00f3n en c\u00e9lulas GBM aisladas, se estudiar\u00e1 la toxicidad in vivo de los nanocompuestos determinando diferentes par\u00e1metros bioqu\u00edmicos en el plasma de ratones que proporcionar\u00e1n informaci\u00f3n sobre los perfiles bioqu\u00edmicos lip\u00eddicos, renales y hep\u00e1ticos. Adem\u00e1s, se estudiar\u00e1n posibles acciones farmacol\u00f3gicas\/t\u00f3xicas adicionales de los nanocompuestos. Se utilizar\u00e1n nanocompuestos que carecen de toxicidad in vivo para administrar siRNA a xenoinjertos sing\u00e9nicos en ratones o a xenoinjertos de GBM derivados de pacientes en ratones inmunodeficientes. El uso de tumores de pacientes con GBM y la correlaci\u00f3n con los datos cl\u00ednicos de esos pacientes aumentar\u00e1n la relevancia de los resultados obtenidos en este proyecto y la probabilidad de que, en su momento, lleguen al \u00e1mbito cl\u00ednico.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto NANO4GLIO - Efecto terap\u00e9utico de complejos SiRNA\/nanopart\u00edculas el c\u00e9lulas de gliobastoma\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/5leBWEzSzOM?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA: <\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1514\" height=\"381\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm.png\" alt=\"\" class=\"wp-image-9499\" style=\"width:233px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm.png 1514w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm-300x75.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm-1024x258.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_uclm-768x193.png 768w\" sizes=\"(max-width: 1514px) 100vw, 1514px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"710\" height=\"624\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/USC.jpg\" alt=\"\" class=\"wp-image-2173\" style=\"width:141px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/USC.jpg 710w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/USC-300x264.jpg 300w\" sizes=\"(max-width: 710px) 100vw, 710px\" \/><\/figure>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"582\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/US-marca-principal.png\" alt=\"\" class=\"wp-image-9344\" style=\"width:130px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/US-marca-principal.png 669w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/US-marca-principal-300x261.png 300w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 5 (LA5)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Nanopart\u00edculas para administrar ARNip a xenoinjertos de glioblastoma derivados de pacientes<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> Glioblastoma, siRNA, nanopart\u00edculas, nanomedicina.<\/p>\n","protected":false},"author":15,"featured_media":11599,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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