{"id":11211,"date":"2024-04-08T18:14:18","date_gmt":"2024-04-08T18:14:18","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/epigecu\/"},"modified":"2025-06-13T08:04:14","modified_gmt":"2025-06-13T08:04:14","slug":"epigecu","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/epigecu\/","title":{"rendered":"EPIGECU"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"175\" height=\"177\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/and6.png\" alt=\"\" class=\"wp-image-11188\" style=\"width:303px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Implementaci\u00f3n de tecnolog\u00edas de accesibilidad de la cromatina a nivel de c\u00e9lula \u00fanica en estrategias de medicina personalizada<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 3:<\/strong> PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS INTERACCIONES F\u00c1RMACO-DIANA.<br><strong>Palabras clave: <\/strong>cromatina; c\u00e9lula \u00fanica; medicina personalizada; oncolog\u00eda; epigen\u00e9tica.<br><strong>Coordina: <\/strong>Centro Andaluz de Biolog\u00eda Molecular y Medicina Regenerativa; Consejo Superior de Investigaciones Cient\u00edficas.<br><strong>Participa:<\/strong> Instituto de Biomedicina de Sevilla (Andaluc\u00eda); Hospital Universitario Virgen del Roc\u00edo (Andaluc\u00eda); Servicio Andaluz de Salud (Andaluc\u00eda); Universidad de Sevilla (Andaluc\u00eda); Universidad Pablo Olivade (Andaluc\u00eda).<br><strong>Persona de contacto: <\/strong>Dr. Jos\u00e9 Carlos Reyes (jose.reyes@cabimer.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>Las t\u00e9cnicas cl\u00e1sicas de anatom\u00eda patol\u00f3gica usadas rutinariamente en la cl\u00ednica se basan en las diferentes morfolog\u00edas y caracter\u00edsticas de tinci\u00f3n de los diferentes tipos celulares y tejidos, y en el uso de anticuerpos contra determinados marcadores. Sin embargo, las recientes t\u00e9cnicas de an\u00e1lisis del transcriptoma y del epigenoma a nivel de c\u00e9lula \u00fanica sugieren que la cantidad de tipos celulares existentes es muy superior a la previamente identificada por t\u00e9cnicas cl\u00e1sicas. Las tecnolog\u00edas OMICAS de c\u00e9lula \u00fanica constituyen un cambio de paradigma para aproximarse a la comprensi\u00f3n del funcionamiento de las diferentes escalas organizativas que constituyen un ser vivo, desde la escala celular a la de \u00f3rgano. La aplicaci\u00f3n de estas tecnolog\u00edas a la cl\u00ednica est\u00e1 en sus comienzos, pero tiene un incuestionable futuro especialmente en algunas \u00e1reas cl\u00ednicas donde comprender la heterogeneidad de la poblaci\u00f3n celular es esencial. Un ejemplo paradigm\u00e1tico es la oncolog\u00eda donde la heterogeneidad gen\u00e9tica y epigen\u00e9tica de las c\u00e9lulas tumorales origina desde comportamientos metast\u00e1ticos a resistencias a tratamientos. La tecnolog\u00eda denominada ATAC-seq de c\u00e9lula \u00fanica (scATAC-seq) permite el conocimiento de las regiones accesibles del genoma, que en su mayor\u00eda son las regiones reguladoras: promotores, potenciadores y aisladores. Estos elementos son espec\u00edficos del tipo celular y cambian seg\u00fan el grado de diferenciaci\u00f3n celular, as\u00ed como por efecto de rutas de se\u00f1alizaci\u00f3n. Conocer el repertorio de elementos reguladores accesibles de una c\u00e9lula es tanto como conocer sus potencialidades y caracter\u00edsticas, y es complementario a conocer su transcriptoma y su proteoma. El objetivo general de este proyecto es implementar metodolog\u00edas de scATAC-seq en muestras de origen cl\u00ednico o modelos derivados de ellas. Como prueba de concepto usaremos xenoinjertos derivados de pacientes, un modelo de gran inter\u00e9s para dilucidar nuevos tratamientos y biomarcadores en oncolog\u00eda. Los resultados se pondr\u00e1n en com\u00fan y se comparar\u00e1n con los de otros subproyectos que usen diferentes tecnolog\u00edas de c\u00e9lula \u00fanica.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto EPIGECU - tecnolog\u00edas de accesibilidad de la cromatina a nivel de c\u00e9lula \u00fanica\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/-jsq2intuKc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"304\" height=\"124\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cabimer.jpg\" alt=\"\" class=\"wp-image-11183\" style=\"width:181px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cabimer.jpg 304w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/cabimer-300x122.jpg 300w\" sizes=\"(max-width: 304px) 100vw, 304px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"301\" height=\"55\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/csic-1.png\" alt=\"\" class=\"wp-image-11037\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"213\" height=\"114\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/IBIS-3.png\" alt=\"\" class=\"wp-image-10977\" style=\"width:185px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"205\" height=\"143\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/HOSPITALVIRGEN-1.png\" alt=\"\" class=\"wp-image-10949\" style=\"width:214px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"254\" height=\"78\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/servicio-andaluz-salud-3.png\" alt=\"\" class=\"wp-image-10966\" style=\"width:247px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"669\" height=\"582\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/US-marca-principal.png\" alt=\"\" class=\"wp-image-9344\" style=\"width:157px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/US-marca-principal.png 669w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/US-marca-principal-300x261.png 300w\" sizes=\"(max-width: 669px) 100vw, 669px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"175\" height=\"122\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/UNIVERSIDADPABLOOLIVADE-1.jpg\" alt=\"\" class=\"wp-image-11027\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 3 (LA3)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Implementaci\u00f3n de tecnolog\u00edas de accesibilidad de la cromatina a nivel de c\u00e9lula \u00fanica en estrategias de medicina personalizada\n<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> cromatina; c\u00e9lula \u00fanica; medicina personalizada; oncolog\u00eda; epigen\u00e9tica.<\/p>\n","protected":false},"author":15,"featured_media":11189,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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