{"id":11174,"date":"2024-04-08T18:00:31","date_gmt":"2024-04-08T18:00:31","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/ttcu-clin\/"},"modified":"2025-06-13T07:58:10","modified_gmt":"2025-06-13T07:58:10","slug":"ttcu-clin","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/ttcu-clin\/","title":{"rendered":"TRANSECU"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"318\" height=\"187\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/05\/transecuu.png\" alt=\"\" class=\"wp-image-12213\" style=\"width:303px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/05\/transecuu.png 318w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/05\/transecuu-300x176.png 300w\" sizes=\"(max-width: 318px) 100vw, 318px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Implementaci\u00f3n de tecnolog\u00edas de transcript\u00f3mica a nivel de c\u00e9lula \u00fanica a partir de muestras cl\u00ednicas<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 2:<\/strong> IMPLEMENTACI\u00d3N Y AN\u00c1LISIS DE BASES DE DATOS EN MEDICINA DE PRECISI\u00d3N.<br>L\u00ednea de actuaci\u00f3n complementaria: LA4. Desarrollo de modelos biol\u00f3gicos para cribado y estudio de la actividad de mol\u00e9culas terap\u00e9uticas.<br><br><strong>Palabras clave:<\/strong> medicina de precisi\u00f3n, transferencia cl\u00ednica, transcript\u00f3mica, muestras cl\u00ednicas.<br><strong>Coordina: <\/strong>Centro Andaluz de Biolog\u00eda del Desarrollo (CABD); Consejo Superior de Investigaciones Cient\u00edficas.<br><strong>Participa:<\/strong> Instituto de Biomedicina de Sevilla (Andaluc\u00eda); Hospital Universitario Virgen del Roc\u00edo (Andaluc\u00eda); Universidad de C\u00e1diz (Andaluc\u00eda); Universidad de Ja\u00e9n (Andaluc\u00eda); Universidad de M\u00e1laga (Andaluc\u00eda).<br><strong>Persona de contacto: <\/strong>Dr. Javier L\u00f3pez-R\u00edos Moreno (jloprio@upo.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>El estudio anatomopatol\u00f3gico de biopsias y resecciones quir\u00fargicas constituye una herramienta cl\u00ednica fundamental para el diagn\u00f3stico y pron\u00f3stico de las enfermedades humanas. Los Servicios de Anatom\u00eda Patol\u00f3gica han ido complementando el an\u00e1lisis histopatol\u00f3gico de la morfolog\u00eda y composici\u00f3n tisular y celular con t\u00e9cnicas inmunohistoqu\u00edmicas y de patolog\u00eda molecular, incluyendo el uso de secuenciaci\u00f3n masiva de paneles de genes implicados en patolog\u00edas concretas con el fin de identificar a nivel gen\u00f3mico mutaciones espec\u00edficas o variantes de riesgo. La significancia cl\u00ednica de estas variantes o sus combinaciones reside en que proporcionan informaci\u00f3n sobre el diagn\u00f3stico del paciente, la prognosis de la enfermedad o la respuesta de la misma a tratamientos terap\u00e9uticos espec\u00edficos. M\u00e1s recientemente, se ha introducido el an\u00e1lisis transcript\u00f3mico global a partir de muestras homogenizadas (RNA-seq), con el fin de identificar genes diferencialmente expresados entre el tejido patol\u00f3gico y el sano. Este tipo de estudios, todav\u00eda no rutinario en la cl\u00ednica, presentan la desventaja conceptual de que, al realizarse a partir de tejidos complejos, carecen de resoluci\u00f3n celular, particularmente dif\u00edcil de soslayar en el caso de tumores. La tecnolog\u00eda transcript\u00f3mica a nivel de c\u00e9lula \u00fanica (scRNA-seq) est\u00e1 revolucionando el estudio de los procesos biol\u00f3gicos al proporcionar un nivel de resoluci\u00f3n sin igual a la hora de definir la complejidad celular de tejidos. Estas tecnolog\u00edas, de r\u00e1pida implantaci\u00f3n en el \u00e1mbito acad\u00e9mico, est\u00e1n permitiendo un entendimiento fundamental de los procesos del desarrollo, la homeostasis tisular, el envejecimiento y las bases moleculares y celulares de procesos patol\u00f3gicos. El objetivo de este proyecto es capitalizar la experiencia en la generaci\u00f3n y an\u00e1lisis de datos de scRNAseq para la implementaci\u00f3n de protocolos robustos que permitan acceder a estudios de tipo scRNAseq a partir de muestras humanas de diferente origen, incluyendo muestras fijadas y parafinadas, el tipo de muestra m\u00e1s compleja para procesar, pero tambi\u00e9n el m\u00e1s relevante para la transferencia al uso cl\u00ednico.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto TRANSECU -  Implementaci\u00f3n de tecnolog\u00edas de transcript\u00f3mica a nivel de c\u00e9lula \u00fanica\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/DGU8XMcktAs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"163\" height=\"250\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/LOGO-CABD.JPG_849840519-1.jpg\" alt=\"\" class=\"wp-image-11032\" style=\"width:111px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"301\" height=\"55\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/csic-1.png\" alt=\"\" class=\"wp-image-11037\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"213\" height=\"114\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/IBIS-3.png\" alt=\"\" class=\"wp-image-10977\" style=\"width:185px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"205\" height=\"143\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/HOSPITALVIRGEN-1.png\" alt=\"\" class=\"wp-image-10949\" style=\"width:214px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"99\" height=\"115\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/uca.jpg\" alt=\"\" class=\"wp-image-10895\" style=\"width:126px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"187\" height=\"141\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/jaen-1.png\" alt=\"\" class=\"wp-image-11093\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"318\" height=\"59\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/malaga.png\" alt=\"\" class=\"wp-image-11165\" style=\"width:340px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/malaga.png 318w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/malaga-300x56.png 300w\" sizes=\"(max-width: 318px) 100vw, 318px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 2 (LA2)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Implementaci\u00f3n de tecnolog\u00edas de transcript\u00f3mica a nivel de c\u00e9lula \u00fanica a partir de muestras cl\u00ednicas.\n<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> medicina de precisi\u00f3n, transferencia cl\u00ednica, transcript\u00f3mica, muestras cl\u00ednicas.<\/p>\n","protected":false},"author":15,"featured_media":12214,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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