{"id":10940,"date":"2024-04-08T07:50:49","date_gmt":"2024-04-08T07:50:49","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/adgut\/"},"modified":"2025-06-18T10:32:38","modified_gmt":"2025-06-18T10:32:38","slug":"adgut","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/adgut\/","title":{"rendered":"ADGUT"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1118\" height=\"629\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imagen1.jpg\" alt=\"\" class=\"wp-image-10743\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imagen1.jpg 1118w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imagen1-300x169.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imagen1-1024x576.jpg 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imagen1-768x432.jpg 768w\" sizes=\"(max-width: 1118px) 100vw, 1118px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Desarrollo de modelos personalizados para el estudio del eje microbiota-intestino-cerebro en la progresi\u00f3n de trastornos cognitivos asociados a la enfermedad de Alzheimer<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 4:<\/strong>  DESARROLLO DE MODELOS BIOL\u00d3GICOS PARA CRIBADO Y ESTUDIO DE LA ACTIVIDAD DE MOL\u00c9CULAS TERAP\u00c9UTICAS<br><br><strong>Palabras clave:<\/strong> microbiota; Alzheimer; probi\u00f3ticos; envejecimiento.<br><strong>Coordina: <\/strong>EURECAT Centre Tecnol\u00f2gic de Catalunya<br><strong>Participa:<\/strong> Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Girona Dr. Josep Trueta (IDIBGI) (Catalu\u00f1a) y AB-BIOTICS<br><strong>Persona de contacto: <\/strong>Jordi Mayneris Perxachs (jmayneris@idibgi.org)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>La enfermedad de Alzheimer (AD) es una enfermedad neurodegenerativa incurable con una etiolog\u00eda a\u00fan poco conocida. Es la causa m\u00e1s com\u00fan de demencia, cuya prevalencia se prev\u00e9 que se duplique cada 20 a\u00f1os, llegando a 82 millones de personas en 2030. Los pacientes muestran deterioros progresivos de la memoria y deterioro cognitivo que manifiestan en dos etapas tempranas: Deterioro Cognitivo Subjetivo (SCD) y Deterioro Cognitivo Leve (MCI). Diferentes estudios han identificado la existencia de asociaciones relevantes entre la microbiota intestinal (MI), el MCI y la AD, que se explican mediante diferentes mecanismos que vinculan la actividad de la MI con la modulaci\u00f3n del sistema inmunitario.<\/p>\n\n\n\n<p>La complejidad de la interacci\u00f3n entre MI y la progresi\u00f3n de alteraciones cognitivas dificulta la generaci\u00f3n de modelos precl\u00ednicos para el desarrollo de terapias. Por ello, el objetivo principal del proyecto ADGUT es desarrollar modelos precl\u00ednicos que, combinados, permitan el cribado de terapias para la prevenci\u00f3n de la progresi\u00f3n de la enfermedad de AD y su evaluaci\u00f3n personalizada. Para alcanzar este objetivo general se plantean los siguientes objetivos espec\u00edficos: (1) Establecer modelos de AD en Drosophila melanogaster como organismo de cribado de terapias preventivas contra el desarrollo de neurodegeneraci\u00f3n asociada a AD. (2) Estudiar la aplicaci\u00f3n de t\u00e9cnicas de trasplante de MI humana a modelos murinos de AD como estrategia para el estudio de terapias personalizadas. Para ello, se recurrir\u00e1 a herramientas de biolog\u00eda molecular, bioqu\u00edmica y tecnolog\u00edas \u00f3micas para la generaci\u00f3n y caracterizaci\u00f3n de los modelos, incluyendo un caso pr\u00e1ctico de modulaci\u00f3n de la MI mediante probi\u00f3ticos.<\/p>\n\n\n\n<p>As\u00ed, ADGUT permitir\u00e1 establecer un marco precl\u00ednico para el cribado y posterior evaluaci\u00f3n de tratamientos personalizados en base a la interacci\u00f3n entre MI y alteraciones cognitivas.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto ADGUT - Modelos personalizados para el estudio del eje microbiota-intestino-cerebro\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/PjLLZS4PjDc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"401\" height=\"126\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/EURECAT.png\" alt=\"\" class=\"wp-image-10861\" style=\"width:253px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/EURECAT.png 401w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/EURECAT-300x94.png 300w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"842\" height=\"271\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/IDIBGI.jpg\" alt=\"\" class=\"wp-image-10866\" style=\"width:192px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/IDIBGI.jpg 842w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/IDIBGI-300x97.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/IDIBGI-768x247.jpg 768w\" sizes=\"(max-width: 842px) 100vw, 842px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2025\/06\/AB-BIOTICS-LOGO-optimized.webp\" alt=\"\" class=\"wp-image-19700\" style=\"width:178px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2025\/06\/AB-BIOTICS-LOGO-optimized.webp 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2025\/06\/AB-BIOTICS-LOGO-optimized-150x150.webp 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 4 (LA4)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Desarrollo de modelos personalizados para el estudio del eje microbiota-intestino-cerebro en la progresi\u00f3n de trastornos cognitivos asociados a la enfermedad de Alzheimer.<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> microbiota; Alzheimer; probi\u00f3ticos; envejecimiento.<\/p>\n","protected":false},"author":15,"featured_media":10744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[244],"tags":[195,198],"class_list":["post-10940","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-eu","tag-catalunya-eu","tag-modelos-biologicos-eu"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts\/10940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/comments?post=10940"}],"version-history":[{"count":5,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts\/10940\/revisions"}],"predecessor-version":[{"id":20420,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/posts\/10940\/revisions\/20420"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/media\/10744"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/media?parent=10940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/categories?post=10940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/eu\/wp-json\/wp\/v2\/tags?post=10940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}