{"id":10733,"date":"2024-04-04T11:54:28","date_gmt":"2024-04-04T11:54:28","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/lenti-up\/"},"modified":"2025-06-12T13:39:31","modified_gmt":"2025-06-12T13:39:31","slug":"lenti-up","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/lenti-up\/","title":{"rendered":"LENTI-UP"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"827\" height=\"712\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/lup.png\" alt=\"\" class=\"wp-image-10717\" style=\"border-radius:7px;width:298px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/lup.png 827w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/lup-300x258.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/lup-768x661.png 768w\" sizes=\"(max-width: 827px) 100vw, 827px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Optimizaci\u00f3n de la fabricaci\u00f3n de vectores lentivirales para la producci\u00f3n de CAR-T u otras terapias celulares<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 6:<\/strong>  T\u00c9CNICAS Y PROCESOS PARA TERAPIAS AVANZADAS Y DIRIGIDAS, FORMACI\u00d3N QUIR\u00daRGICA Y ROB\u00d3TICA M\u00c9DICA.<br><br><strong>Palabras clave:<\/strong> c\u00e1nceres hematol\u00f3gicos; c\u00e9lulas CAR-T; vectores lentivirales, biorreactores; Normas de Correcta Fabricaci\u00f3n (NCF).<br><strong>Coordina:<\/strong>  Cl\u00ednic Barcelona; Institut d&#8217;Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS).<br><strong>Participa:<\/strong> LEITAT; Hospital Sant Joan de D\u00e9u (Catalu\u00f1a); Complejo Hospitalario y Universitario de Santiago (CHUS-Galaria) (Galicia).<br><strong>Persona de contacto:<\/strong> Manel Juan y Hugo Calder\u00f3n (mjuan@clinic.cat \/ hcalderon@clinic.cat) <\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>La inmunoterapia ha transformado el tratamiento del c\u00e1ncer al aprovechar el sistema inmunol\u00f3gico para atacar las c\u00e9lulas tumorales. Un avance fundamental en este \u00e1mbito es la terapia celular adoptiva, que emplea particularmente linfocitos T modificados con Receptores de Ant\u00edgeno Quim\u00e9rico (CAR), que ha demostrado ser altamente efectiva contra los c\u00e1nceres hematol\u00f3gicos.<br>El Hospital Cl\u00ednic de Barcelona ha liderado en Europa el desarrollo acad\u00e9mico de c\u00e9lulas CAR-T dirigidas al ant\u00edgeno CD19 prevalente en las neoplasias de c\u00e9lulas B (ARI0001). Obtener la autorizaci\u00f3n bajo exenci\u00f3n hospitalaria de la Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (AEMPS) marc\u00f3 un hito significativo. Adem\u00e1s, obtener la designaci\u00f3n PRIME de la Agencia Europea de Medicamentos (EMA) para nuestro producto desarrollado acad\u00e9micamente subraya su potencial para proporcionar opciones de tratamiento asequibles y de atenci\u00f3n inmediata, revolucionando la atenci\u00f3n al paciente y el impacto en la sociedad.<br>Ampliando nuestro enfoque, aspiramos a desarrollar terapias con c\u00e9lulas CAR-T accesibles para diversos tipos de c\u00e1ncer. Por ejemplo, estamos evaluando cl\u00ednicamente ARI0002 para el mieloma m\u00faltiple positivo para BCMA y otras neoplasias de c\u00e9lulas B.<br>Sin embargo, el proceso de producci\u00f3n de estos medicamentos personalizados presenta desaf\u00edos. Implica transducir linfocitos T aut\u00f3logos con vectores lentivirales (VLs) que contienen la secuencia CAR, todo ello bajo estrictas Normas de Correcta Fabricaci\u00f3n (NCF) en instalaciones con salas blancas. Con la creciente demanda y las perspectivas futuras prometedoras, es imperativo escalar el proceso de producci\u00f3n de VL para atender a una poblaci\u00f3n de pacientes m\u00e1s amplia mientras se reduce el coste.<br>Juntamente con Leitat, nuestro primer objetivo es implementar un sistema de producci\u00f3n de VLs en biorreactores cumpliendo NCF y con el fin de obtener una mayor calidad del producto. El segundo objetivo, consiste en validar la producci\u00f3n de la terapia CAR-T con estos nuevos VLs en el Hospital Sant Juan de Deu y Complejo Hospitalario y Universitario de Santiago. Esta expansi\u00f3n no solo aumentar\u00e1 la accesibilidad al tratamiento, sino que tambi\u00e9n impulsar\u00e1 los avances en terapias con c\u00e9lulas CAR-T y gen\u00e9ticas que utilizan VLs. En \u00faltima instancia, nuestros esfuerzos tienen como objetivo impactar positivamente a los pacientes y la sociedad mejorando el acceso al tratamiento y optimizando los procesos de producci\u00f3n, aliviando as\u00ed los costos para los sistemas de salud nacionales.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto LENTI UP - Fabricaci\u00f3n de vectores lentivirales para la producci\u00f3n de CAR-T\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/StY7ZHXVINo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"546\" height=\"234\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-11-131405.png\" alt=\"\" class=\"wp-image-9169\" style=\"width:240px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-11-131405.png 546w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-11-131405-300x129.png 300w\" sizes=\"(max-width: 546px) 100vw, 546px\" \/><\/figure>\n\n\n\n<div style=\"height:37px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"278\" height=\"107\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/idibaps-1.png\" alt=\"\" class=\"wp-image-1390\" style=\"width:209px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"520\" height=\"270\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/sant_joan_de_deu_1669114427.png\" alt=\"\" class=\"wp-image-9254\" style=\"width:202px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/sant_joan_de_deu_1669114427.png 520w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/sant_joan_de_deu_1669114427-300x156.png 300w\" sizes=\"(max-width: 520px) 100vw, 520px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"225\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/galaria.png\" alt=\"\" class=\"wp-image-10727\" style=\"width:199px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/galaria.png 225w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/galaria-150x150.png 150w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1614\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-scaled.jpg\" alt=\"\" class=\"wp-image-10722\" style=\"width:201px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-scaled.jpg 2560w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-300x189.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-1024x646.jpg 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-768x484.jpg 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-1536x968.jpg 1536w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/Imegen_de_el_Logo_de_Leitat-2048x1291.jpg 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 6 (LA6)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Optimizaci\u00f3n de la fabricaci\u00f3n de vectores lentivirales para la producci\u00f3n de CAR-T u otras terapias celulares.\n<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> c\u00e1nceres hematol\u00f3gicos; c\u00e9lulas CAR-T; vectores lentivirales, biorreactores; Normas de Correcta Fabricaci\u00f3n (NCF).<\/p>\n","protected":false},"author":15,"featured_media":10718,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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