{"id":10019,"date":"2024-03-22T10:55:27","date_gmt":"2024-03-22T10:55:27","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=10019"},"modified":"2025-06-16T13:31:26","modified_gmt":"2025-06-16T13:31:26","slug":"car-m-anti-egfr","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/eu\/car-m-anti-egfr\/","title":{"rendered":"CAR-M-anti-EGFR\u00a0"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"486\" height=\"358\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-113945.png\" alt=\"\" class=\"wp-image-9994\" style=\"border-radius:7px;width:298px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-113945.png 486w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-113945-300x221.png 300w\" sizes=\"(max-width: 486px) 100vw, 486px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Terapia celular personalizada con c\u00e9lulas mieloides CAR-M anti-EGFR para tumores s\u00f3lidos.<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 6:<\/strong> T\u00c9CNICAS Y PROCESOS PARA TERAPIAS AVANZADAS Y DIRIGIDAS, FORMACI\u00d3N QUIR\u00daRGICA Y ROB\u00d3TICA M\u00c9DICA<br><br><strong>Palabras clave:<\/strong> C\u00e1ncer de pulm\u00f3n, terapia celular, macr\u00f3fagos, inmunoterapia antitumoral\u00a0<br><strong>Coordina:<\/strong> Instituto de investigaci\u00f3n biom\u00e9dica de A Coru\u00f1a (inibic)<br><strong>Participa:<\/strong> Universidades de Santiago de Compostela (USC) (Galicia), Galaria empresa p\u00fablica de servizos sanitarios (Galicia), Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) (Catalu\u00f1a)<br><strong>Persona de contacto:<\/strong> Fernando Torres And\u00f3n (fernando.torres.andon@sergas.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>Este proyecto se centra en el desarrollo de una nueva terapia celular utilizando monocitos\/macr\u00f3fagos para el tratamiento de tumores s\u00f3lidos, incluyendo estudios precl\u00ednicos en modelos de c\u00e1ncer de pulm\u00f3n. A lo largo de los \u00faltimos 5 a\u00f1os se han aprobado varias terapias celulares, basadas en c\u00e9lulas T (CAR-T), para el tratamiento de mieloma m\u00faltiple, leucemia de c\u00e9lulas B y linfomas. Sin embargo, su limitada estabilidad, escasa capacidad de extravasaci\u00f3n e infiltraci\u00f3n, la heterogeneidad antig\u00e9nica y naturaleza inmunosupresora del microambiente tumoral causada en gran parte por los macr\u00f3fagos asociados a tumores (TAMs), representan obst\u00e1culos significativos que impiden la utilizaci\u00f3n cl\u00ednica de CAR-T en tumores s\u00f3lidos.<\/p>\n\n\n\n<p>Para afrontar estas dificultades, planteamos el desarrollo y evaluaci\u00f3n de una nueva terapia celular basada en el uso de monocitos\/macr\u00f3fagos dirigidos a c\u00e9lulas tumorales con sobreexpresi\u00f3n de EGFR (CAR-M), una de las mutaciones m\u00e1s comunes en c\u00e1ncer de pulm\u00f3n. Nuestro plan de trabajo incluye 4 objetivos principales con la finalidad de: 1) desarrollar monocitos\/macr\u00f3fagos con prolongada viabilidad y actividad antitumoral in vitro, 2) implementar y validar CAR-M anti-EGFR en modelos 2D y 3D in vitro, 3) evaluar la biodistribuci\u00f3n, infiltraci\u00f3n y actividad antitumoral de CAR-M in vivo en modelos pre-cl\u00ednicos murinos inmunodeficientes e inmunocompetentes de c\u00e1ncer de pulm\u00f3n, 4) validar la actividad antitumoral de CAR-M en cultivos ex vivo preparados a partir de tumores de pacientes resistentes a terapias actuales (ej. quimioterapia, inmunoterapia, radioterapia o terapias dirigidas). <\/p>\n\n\n\n<p>Con esta estrategia (CAR-M), gracias a la propia naturaleza de los monocitos\/macr\u00f3fagos (frente a CAR-Ts), esperamos conseguir su reclutamiento eficaz y r\u00e1pida infiltraci\u00f3n hacia el centro del tumor, fagocitosis de c\u00e9lulas tumorales y presentaci\u00f3n de ant\u00edgenos, remodelaci\u00f3n de la matriz extracelular y una polarizaci\u00f3n M1-antitumoral desencadenando una eficaz respuesta inmune innata y adaptativa contra el tumor. En caso de \u00e9xito, esta terapia celular CAR-M anti-EGFR tambi\u00e9n podr\u00e1 aplicarse al tratamiento de otros tumores s\u00f3lidos.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto CAR-M-ANTI-EGFR -Terapia celular para tumores s\u00f3lidos con c\u00e9lulas mieloides CAR-M anti-EGFR\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/PoXHYpwVhho?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"512\" height=\"314\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/unnamed.png\" alt=\"\" class=\"wp-image-9999\" style=\"width:165px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/unnamed.png 512w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/unnamed-300x184.png 300w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1200\" height=\"779\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg_-1.png\" alt=\"\" class=\"wp-image-10004\" style=\"width:144px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg_-1.png 1200w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg_-1-300x195.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg_-1-1024x665.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg_-1-768x499.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"77\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/descarga-6.png\" alt=\"\" class=\"wp-image-10009\" style=\"width:172px;height:auto\"\/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"607\" height=\"330\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-115117.png\" alt=\"\" class=\"wp-image-10014\" style=\"width:169px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-115117.png 607w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-115117-300x163.png 300w\" sizes=\"(max-width: 607px) 100vw, 607px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 6 (LA6)<\/i><\/p>\n<p><\u00a0><br \/>\n<\/p>\n<p>Terapia celular personalizada con c\u00e9lulas mieloides CAR-M anti-EGFR para tumores s\u00f3lidos.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> C\u00e1ncer de pulm\u00f3n, terapia celular, macr\u00f3fagos, inmunoterapia antitumoral.<\/p>\n","protected":false},"author":3,"featured_media":9995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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