{"id":9531,"date":"2024-03-22T10:23:25","date_gmt":"2024-03-22T10:23:25","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=9531"},"modified":"2025-06-16T13:31:39","modified_gmt":"2025-06-16T13:31:39","slug":"magnet-il-18","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/en\/magnet-il-18\/","title":{"rendered":"MAGNET-IL-18"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"529\" height=\"527\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-19-172445.png\" alt=\"\" class=\"wp-image-9513\" style=\"border-radius:7px;width:298px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-19-172445.png 529w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-19-172445-300x300.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-19-172445-150x150.png 150w\" sizes=\"(max-width: 529px) 100vw, 529px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Liberaci\u00f3n de citoquina IL-18 en medio celular mediante microestructuras magn\u00e9ticas para el estudio de la respuesta inflamatoria<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 5: <\/strong>DESARROLLO DE NANOF\u00c1RMACOS, BIODISTRIBUCI\u00d3N, TOXICIDAD Y ACCIONES TERAP\u00c9UTICAS EN MODELOS DE PATOLOG\u00cdA<br><br><strong>Palabras clave:<\/strong> Nanoestructuras magn\u00e9ticas, procesos de internalizaci\u00f3n, respuesta inflamatoria.<br><strong>Coordina:<\/strong> cinbio<br><strong>Participa:<\/strong> Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (Galicia), Instituto de Biomedicina de Sevilla (IBIS) (Andaluc\u00eda).<br><strong>Persona de contacto: <\/strong>Ver\u00f3nica Salgueiri\u00f1o Maceira (vsalgue@uvigo.gal)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>Las nano y microestructuras magn\u00e9ticas est\u00e1n siendo ampliamente utilizadas en biomedicina; en terapia celular e hipertermia magn\u00e9tica, para liberaci\u00f3n de f\u00e1rmacos y en t\u00e9cnicas de imagen. En particular, esta propuesta plantea la internalizaci\u00f3n de estructuras magn\u00e9ticas portadoras de citoquina IL-18 en c\u00e9lulas, mediante procesos de endocitosis o mediante una internalizaci\u00f3n forzada magn\u00e9ticamente. <\/p>\n\n\n\n<p>Estas rutas de internalizaci\u00f3n suponen tener las microestructuras atrapadas en lisosomas o libres en el citoplasma, permitiendo estudiar la respuesta celular a la presencia de esta citoquina pro-inflamatoria en funci\u00f3n de su localizaci\u00f3n. Se consideran dos tipos de estructuras magn\u00e9ticas en base a su tama\u00f1o, topograf\u00eda superficial (lisa o con morfolog\u00eda de puntas) y respuesta magn\u00e9tica, ya que todos los par\u00e1metros influyen tambi\u00e9n en la internalizaci\u00f3n y localizaci\u00f3n intracelular. Las estructuras magn\u00e9ticas portar\u00e1n las mol\u00e9culas de IL-18: a) fijadas directamente sobre el material magn\u00e9tico, con concentraciones definidas por tanto en funci\u00f3n de la topograf\u00eda de superficie, y b) ancladas en la superficie de una capa externa de redes org\u00e1nicas covalentes COFs (del ingl\u00e9s, covalent organic frameworks). <\/p>\n\n\n\n<p>Ambas opciones permitir\u00e1n la liberaci\u00f3n de la IL-18 utilizando distintos mecanismos qu\u00edmicos (en funci\u00f3n de la naturaleza qu\u00edmica del material magn\u00e9tico o COFs) o haciendo uso de una liberaci\u00f3n controlada de calor, en base al grosor de la capa de COF, modificando as\u00ed los niveles de IL-18. Los niveles de IL-18, libre en plasma o en ves\u00edculas extracelulares, podr\u00edan actuar como biomarcadores de control de infecci\u00f3n por VIH, teniendo en cuenta que la IL-18 se libera tras la activaci\u00f3n del inflamasoma NLPR3 y la acci\u00f3n de la caspasa-1. Por tanto, es de especial inter\u00e9s evaluar la respuesta celular a IL-18 y su impacto en la respuesta inflamatoria y las comorbilidades en personas que viven con VIH (PWH).<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto MAGNET-IL-18 - Liberaci\u00f3n de citoquina IL-18 para el estudio de la respuesta inflamatoria\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/adCZUEWoO5o?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"385\" height=\"123\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo-CINBIO.png\" alt=\"\" class=\"wp-image-9519\" style=\"width:172px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo-CINBIO.png 385w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo-CINBIO-300x96.png 300w\" sizes=\"(max-width: 385px) 100vw, 385px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_IISGS_color.png\" alt=\"\" class=\"wp-image-9524\" style=\"width:142px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_IISGS_color.png 800w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_IISGS_color-300x300.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_IISGS_color-150x150.png 150w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logo_IISGS_color-768x768.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"913\" height=\"371\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2023\/01\/ibis_Andalucia_3.png\" alt=\"\" class=\"wp-image-2466\" style=\"width:165px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2023\/01\/ibis_Andalucia_3.png 913w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2023\/01\/ibis_Andalucia_3-300x122.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2023\/01\/ibis_Andalucia_3-768x312.png 768w\" sizes=\"(max-width: 913px) 100vw, 913px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 5 (LA5)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Liberaci\u00f3n de citoquina IL-18 en medio celular mediante microestructuras magn\u00e9ticas para el estudio de la respuesta inflamatoria.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> Nanoestructuras magn\u00e9ticas, procesos de internalizaci\u00f3n, respuesta inflamatoria.<\/p>\n","protected":false},"author":3,"featured_media":9516,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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