{"id":11481,"date":"2024-07-29T07:52:33","date_gmt":"2024-07-29T07:52:33","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=11481"},"modified":"2025-07-10T08:42:32","modified_gmt":"2025-07-10T08:42:32","slug":"desarrollo-de-farmacos","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/en\/desarrollo-de-farmacos\/","title":{"rendered":"Identificaci\u00f3n y el desarrollo de f\u00e1rmacos espec\u00edficos frente a prote\u00ednas diana asociadas con c\u00e1ncer, enfermedades infecciosas, enfermedades conformacionales, y enfermedades raras o minoritarias"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image alignright size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"797\" height=\"881\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge1-5.png\" alt=\"\" class=\"wp-image-20553\" style=\"border-radius:7px;width:254px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge1-5.png 797w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge1-5-271x300.png 271w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge1-5-768x849.png 768w\" sizes=\"(max-width: 797px) 100vw, 797px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\"><strong>Identificaci\u00f3n y el desarrollo de f\u00e1rmacos espec\u00edficos frente a prote\u00ednas diana asociadas con c\u00e1ncer, enfermedades infecciosas, enfermedades conformacionales, y enfermedades raras o minoritarias<\/strong><\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 3:<\/strong> PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS INTERACCIONES F\u00c1RMACO-DIANA<br><br><strong>Palabras clave:<\/strong> Prote\u00ednas dependientes de zinc, inhibidores alost\u00e9ricos, deacetilasas de prote\u00ednas, cribado molecular experimental, HDAC8, LpxC, Prote\u00ednas intr\u00ednsecamente desordenadas, papel estructural y funcional de regiones desordenadas, chaperonas farmacol\u00f3gicas, MeCP2<br><strong>Coordina:<\/strong> Instituto de Investigaci\u00f3n Sanit\u00e1ria Arag\u00f3n (IISA)<br><strong>Participa:<\/strong> Universidad de Zaragoza (UNIZAR); HU Miguel Servet (Arag\u00f3n); HCU Lozano Blesa (Arag\u00f3n); HU Donostia (Pa\u00eds Vasco); CRCM Marseille (Francia); University of Victoria (Canad\u00e1); CIMUS (Grupo BioFarma \u2013 y Plataforma INNOPHARMA (participan directamente en el PCBAS Galicia)<br><strong>Personas de contacto:<\/strong> Adri\u00e1n Vel\u00e1zquez Campoy (adrianvc@unizar.es) | Olga Abian Franco (oabifra@unizar.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>En esta l\u00ednea estamos trabajando en diversas prote\u00ednas diana para las que estamos tratando de identificar compuestos qu\u00edmicos capaces de modular su actividad y servir como punto de partida para desarrollar nuevos f\u00e1rmacos. Teniendo en cuenta nuestra conexi\u00f3n con el Grupo de Investigaci\u00f3n Traslacional en Patolog\u00eda Digestiva Patolog\u00eda Digestiva (CB06\/04\/0066 CIBERehd, GIIS027 Gobierno de Arag\u00f3n), las prote\u00ednas diana est\u00e1n asociadas con enfermedades digestivas: BFT3, HDAC8, LpxC, y MeCP2.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"658\" height=\"525\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/iisa.png\" alt=\"\" class=\"wp-image-1388\" style=\"width:165px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/iisa.png 658w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/iisa-300x239.png 300w\" sizes=\"(max-width: 658px) 100vw, 658px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"718\" height=\"264\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/logoUZ.png\" alt=\"\" class=\"wp-image-16370\" style=\"width:232px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/logoUZ.png 718w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/logoUZ-300x110.png 300w\" sizes=\"(max-width: 718px) 100vw, 718px\" \/><\/figure>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"825\" height=\"225\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/hospital-universitario-miguel-servet-zaragoza.jpg\" alt=\"\" class=\"wp-image-20533\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/hospital-universitario-miguel-servet-zaragoza.jpg 825w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/hospital-universitario-miguel-servet-zaragoza-300x82.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/hospital-universitario-miguel-servet-zaragoza-768x209.jpg 768w\" sizes=\"(max-width: 825px) 100vw, 825px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"218\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/logoblesa.webp\" alt=\"\" class=\"wp-image-20538\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/logoblesa.webp 600w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/logoblesa-300x109.webp 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"900\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/thio-logo-crcm-def-1600x900-2.jpg\" alt=\"\" class=\"wp-image-20563\" style=\"width:242px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/thio-logo-crcm-def-1600x900-2.jpg 1600w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/thio-logo-crcm-def-1600x900-2-300x169.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/thio-logo-crcm-def-1600x900-2-1024x576.jpg 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/thio-logo-crcm-def-1600x900-2-768x432.jpg 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/thio-logo-crcm-def-1600x900-2-1536x864.jpg 1536w\" sizes=\"(max-width: 1600px) 100vw, 1600px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/h-universitario-donostia-a.png\" alt=\"\" class=\"wp-image-20558\" style=\"width:201px;height:auto\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"299\" height=\"168\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/uiv.png\" alt=\"\" class=\"wp-image-20568\" style=\"width:176px;height:auto\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"415\" height=\"85\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logocimus_0.jpg\" alt=\"\" class=\"wp-image-9404\" style=\"width:248px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logocimus_0.jpg 415w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logocimus_0-300x61.jpg 300w\" sizes=\"(max-width: 415px) 100vw, 415px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 3 (LA3)<\/i><\/p>\n<p><\u00a0><br \/>\n<\/p>\n<p>Nueva estrategia farmacol\u00f3gica contra prote\u00ednas diana dependientes de zinc: inhibidores alost\u00e9ricos de las desacetilasas HDAC8 y LpxC (MCIN, PID2021-127296OB-I00).<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> Prote\u00ednas dependientes de zinc, inhibidores alost\u00e9ricos, deacetilasas de prote\u00ednas, cribado molecular experimental, HDAC8, LpxC<\/p>\n","protected":false},"author":15,"featured_media":20556,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[246],"tags":[268,194],"class_list":["post-11481","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-en","tag-aragon-en","tag-cribado-de-farmacos-en"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/posts\/11481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/comments?post=11481"}],"version-history":[{"count":10,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/posts\/11481\/revisions"}],"predecessor-version":[{"id":21015,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/posts\/11481\/revisions\/21015"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/media\/20556"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/media?parent=11481"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/categories?post=11481"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/en\/wp-json\/wp\/v2\/tags?post=11481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}