{"id":18245,"date":"2024-12-10T08:50:39","date_gmt":"2024-12-10T08:50:39","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/mitosicom\/"},"modified":"2025-10-13T07:34:57","modified_gmt":"2025-10-13T07:34:57","slug":"mitosicom","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/ca\/mitosicom\/","title":{"rendered":"MITOSICOM"},"content":{"rendered":"\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-cover alignfull is-light wp-duotone-unset-1\" style=\"margin-top:0;padding-top:48px;padding-right:48px;padding-bottom:48px;padding-left:48px;min-height:430px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-30 has-background-dim\" style=\"background-color:#40727d\"><\/span><img fetchpriority=\"high\" decoding=\"async\" width=\"278\" height=\"227\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-12.png\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"\" data-object-fit=\"cover\" data-object-position=\"36% 72%\" style=\"object-position:36% 72%;\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-0b562c1c wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-left has-white-color has-text-color\" style=\"font-size:73px;font-style:normal;font-weight:700;letter-spacing:0px;line-height:1;text-transform:uppercase\">\n          MITOSICOM\n          <\/h2>\n<\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Funci\u00f3n mitocondrial en enfermedades sindr\u00f3micas complejas. Detecci\u00f3n de posibles dianas terap\u00e9uticas<\/h2>\n\n\n\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 3:<\/strong> PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS DE INTERACCIONES F\u00c1RMACO-DIANA.<br>L\u00edneas de actuaci\u00f3n complementaria: LA4 desarrollo de modelos biol\u00f3gicos para cribado y estudio de la actividad de mol\u00e9culas terap\u00e9uticas y LA5 Desarrollo de nanof\u00e1rmacos, biodistribuci\u00f3n, toxicidad y acciones terap\u00e9uticas en modelos de patolog\u00eda<br><br><br><strong>Palabras clave:<\/strong> S\u00edndrome de Bardet-Biedl, S\u00edndrome de Alstr\u00f6m, Enfermedad de Fabry, mitocondria, enfermedades raras<br><strong>Coordina:<\/strong> Universidad de Vigo (Uvigo)<br><strong>Participa:<\/strong> Fundaci\u00f3n P\u00fablica Galega de Investigaci\u00f3n Biom\u00e9dica Galicia Sur (Galicia); Instituto de Investigaci\u00f3n de Vall d\u2019Hebron (VHIR) (Catalu\u00f1a)<br><strong>Persona de contacto:<\/strong> Diana Valverde P\u00e9rez (dianaval@uvigo.es)<\/p>\n<\/div>\n<\/div>\n\n\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">RESUMEN PROYECTO<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<p>En las enfermedades raras de tipo sindr\u00f3mico existe una alta heterogeneidad fenot\u00edpica, tanto intrafamiliar como interfamiliar, lo que supone un reto a la hora de dise\u00f1ar terapias adecuadas a cada paciente. En algunos casos se describe diferente severidad en funci\u00f3n del tejido afectado, haciendo m\u00e1s dif\u00edcil en estos casos la adecuada selecci\u00f3n de una terapia individualizada. La posible implicaci\u00f3n de las mitocondrias tanto a nivel morfol\u00f3gico como funcional podr\u00eda ayudar a encontrar una explicaci\u00f3n. El grado de heteroplasmia, la distinta distribuci\u00f3n en los tejidos y anomal\u00edas en su funci\u00f3n podr\u00eda estar detr\u00e1s de esta variabilidad fenot\u00edpica. La identificaci\u00f3n de la base molecular de esta variaci\u00f3n o modulaci\u00f3n del fenotipo nos podr\u00eda ayudar a caracterizar mejor la enfermedad y entender su fisiopatolog\u00eda de tal manera que podamos dise\u00f1ar terapias que favorezcan una medicina personalizada enfocada al paciente o al tejido afectado en cada caso.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto MITOSICOM - Funci\u00f3n mitocondrial en enfermedades sindr\u00f3micas complejas.\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/FZh4OTebYj0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<\/div><h2 class=\"tabtitle\">RESULTADOS DEL PROYECTO<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"485\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/Screenshot-2025-10-13-at-09.29.42-1024x485.png\" alt=\"\" class=\"wp-image-22421\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/Screenshot-2025-10-13-at-09.29.42-1024x485.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/Screenshot-2025-10-13-at-09.29.42-300x142.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/Screenshot-2025-10-13-at-09.29.42-768x364.png 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/Screenshot-2025-10-13-at-09.29.42-1536x727.png 1536w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/Screenshot-2025-10-13-at-09.29.42-2048x970.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>Las enfermedades sindr\u00f3micas, aquellas que presentan un conjunto de s\u00edntomas o caracter\u00edsticas comunes causados por alguna alteraci\u00f3n gen\u00e9tica o metab\u00f3lica, presentan a menudo un reto a la hora de su diagn\u00f3stico debido a la complejidad de los s\u00edntomas y la variabilidad en su presentaci\u00f3n. Muchas de las enfermedades raras sindr\u00f3micas que presentan una elevada heterogeneidad fenot\u00edpica y con un gran solapamiento entre s\u00edntomas, presentan como caracter\u00edstica com\u00fan la disrupci\u00f3n de la correcta actividad mitocondrial y un transporte de membrana deficitario. Este es el caso de los s\u00edndromes de Bardet-Biedl y Alstr\u00f6m y la enfermedad de Fabry. Estas enfermedades no tienen una cura definitiva y es de vital importancia la b\u00fasqueda de diana terap\u00e9uticas que permitan dar a los pacientes opciones de tratamiento.&nbsp;<\/p>\n\n\n\n<p>El objetivo principal del proyecto es evaluar la implicaci\u00f3n mitocondrial en estas enfermedades y la posible determinaci\u00f3n de dianas terap\u00e9uticas que puedan ayudar en el tratamiento de estos pacientes. Para ello, se ha llevado a cabo la caracterizaci\u00f3n del metabolismo mitocondrial en el S\u00edndrome de Bardet Biedl y el S\u00edndrome de Alstr\u00f6m empleando cuatro modelos celulares. De los diversos estudios funcionales del estado energ\u00e9tico y la respiraci\u00f3n mitocondrial se han podido identificar mecanismos y posibles dianas terap\u00e9uticas implicadas en estas patolog\u00edas, lo que abre el campo a la b\u00fasqueda de nuevas terapias para este tipo de enfermedades.&nbsp;<\/p>\n\n\n\n<p>Este proyecto ha sido realizado por investigadores de la Universidad de Vigo con la colaboraci\u00f3n de investigadores del Instituto de Investigaci\u00f3n Sanitaria Galicia Sur y del Instituto de Investigaci\u00f3n del Hospital Vall d\u2019Hebr\u00f3n.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-file alignwide\"><a id=\"wp-block-file--media-d2d9ef5b-64f8-4d7c-bc19-33d91c2d61b7\" href=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/15_Ficha-resumen_MITOSICOM.pdf\">Descargar ficha resultados<\/a><\/div>\n\n\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"230\" height=\"230\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-11.png\" alt=\"\" class=\"wp-image-18232\" style=\"width:253px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-11.png 230w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-11-150x150.png 150w\" sizes=\"(max-width: 230px) 100vw, 230px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"990\" height=\"565\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1.png\" alt=\"\" class=\"wp-image-1392\" style=\"width:178px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1.png 990w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1-300x171.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1-768x438.png 768w\" sizes=\"(max-width: 990px) 100vw, 990px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"377\" height=\"107\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-10.png\" alt=\"\" class=\"wp-image-18227\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-10.png 377w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/12\/imagen-10-300x85.png 300w\" sizes=\"(max-width: 377px) 100vw, 377px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 3 (LA3)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Funci\u00f3n mitocondrial en enfermedades sindr\u00f3micas complejas. Detecci\u00f3n de posibles dianas terap\u00e9uticas.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> S\u00edndrome de Bardet-Biedl, S\u00edndrome de Alstr\u00f6m, Enfermedad de Fabry, mitocondria, enfermedades raras<\/p>\n","protected":false},"author":15,"featured_media":18240,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[245],"tags":[86,182,199,205],"class_list":["post-18245","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-ca","tag-cribado-de-farmacos-ca","tag-galicia-ca","tag-modelos-biologicos-ca","tag-nanofarmacos-ca"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/18245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/comments?post=18245"}],"version-history":[{"count":6,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/18245\/revisions"}],"predecessor-version":[{"id":22428,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/18245\/revisions\/22428"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media\/18240"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media?parent=18245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/categories?post=18245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/tags?post=18245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}