{"id":17966,"date":"2024-11-21T14:55:12","date_gmt":"2024-11-21T14:55:12","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=17966"},"modified":"2025-09-17T08:43:14","modified_gmt":"2025-09-17T08:43:14","slug":"alacarta","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/ca\/alacarta\/","title":{"rendered":"ALACARTA"},"content":{"rendered":"\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-cover alignfull wp-duotone-unset-1\" style=\"margin-top:0;padding-top:48px;padding-right:48px;padding-bottom:48px;padding-left:48px;min-height:430px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-30 has-background-dim\" style=\"background-color:#4a424b\"><\/span><img fetchpriority=\"high\" decoding=\"async\" width=\"567\" height=\"744\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Imatge5.jpg\" class=\"wp-block-cover__image-background wp-post-image\" alt=\"\" data-object-fit=\"cover\" data-object-position=\"36% 72%\" style=\"object-position:36% 72%;\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Imatge5.jpg 567w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Imatge5-229x300.jpg 229w\" sizes=\"(max-width: 567px) 100vw, 567px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-group is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-0b562c1c wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading has-text-align-left has-white-color has-text-color\" style=\"font-size:86px;font-style:normal;font-weight:700;letter-spacing:0px;line-height:1;text-transform:uppercase\">\n          ALACARTA\n          <\/h2>\n<\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Dise\u00f1o de CAR-T acad\u00e9mico anti-claudina 18.2<\/h2>\n\n\n\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 2:<\/strong> IMPLEMENTACI\u00d3N Y AN\u00c1LISIS DE BASES DE DATOS EN MEDICINA DE PRECISI\u00d3N.<br><br><strong>Palabras clave:<\/strong> immunoterapia, CAR-T, Tumores de p\u00e1ncreas y est\u00f3mago, anticuerpo monoclonal<br><strong>Coordina:<\/strong> Universidad de Vigo<br><strong>Participa:<\/strong> Galaria Empresa P\u00fablica de Servicios Sanitarios (Galicia); Hospital Cl\u00ednic (Catalu\u00f1a)<br><strong>Persona de contacto:<\/strong> \u00c1frica Gonz\u00e1lez Fern\u00e1ndez (africa@uvigo.es)<\/p>\n<\/div>\n<\/div>\n\n\n<div class=\"responsive-tabs\">\n<h2 class=\"tabtitle\">RESUMEN PROYECTO<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<p>La terapia CAR-T (del ingl\u00e9s, chimeric antigen receptor) est\u00e1 siendo una revoluci\u00f3n en terapias de leucemias y linfomas, y tiene un extraordinario potencial para tumores s\u00f3lidos y otras patolog\u00edas. Emplea c\u00e9lulas del propio paciente modificadas gen\u00e9ticamente para expresar un receptor quim\u00e9rico que le permita reconocer y eliminar directamente las c\u00e9lulas tumorales. De entre todos los c\u00e1nceres, el de p\u00e1ncreas es uno de los m\u00e1s agresivos, siendo la mayor\u00eda de las terapias ineficaces, al igual que el g\u00e1strico, en sus estadios m\u00e1s avanzados. Las terapias convencionales no han cambiado pr\u00e1cticamente nada el curso de estos c\u00e1nceres, y por tanto es necesario dise\u00f1ar nuevos abordajes terap\u00e9uticos.<\/p>\n\n\n\n<p>El objetivo del proyecto es desarrollar una inmunoterapia dirigida frente a c\u00e1nceres tanto g\u00e1stricos como pancre\u00e1ticos que sobre-expresan una diana en la membrana de las c\u00e9lulas tumorales. Se pretende obtener anticuerpos monoclonales frente a dicha diana, hacer una selecci\u00f3n de estos y dise\u00f1ar un vector viral conteniendo las secuencias de la cadena pesada y ligera del anticuerpo obtenido, junto con genes necesarios para la activaci\u00f3n y supervivencia de los linfocitos T. El vector viral puede ser empleado para modificar gen\u00e9ticamente los linfocitos T del propio paciente para una terapia CAR-T espec\u00edfica. Lo que se pretende es que las c\u00e9lulas CAR-T puedan reconocer y eliminar directamente a las c\u00e9lulas tumorales.<\/p>\n\n\n\n<p>El proyecto pretende tener un impacto en la inmunoterapia dirigida frente a dos c\u00e1nceres muy agresivos que comparten una misma diana, lo que permitir\u00e1 ayudar a beneficiar a los pacientes y a mejorar su calidad de vida, as\u00ed como a disminuir el coste econ\u00f3mico que supone el empleo de otros tratamientos ineficaces.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"ALACARTA - Dise\u00f1o de CAR-T acad\u00e9mico anti-claudina 18.2\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/fHabWcsKado?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<\/div><h2 class=\"tabtitle\">RESULTADOS DEL PROYECTO<\/h2>\n<div class=\"tabcontent\">\n\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"500\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Screenshot-2025-09-17-at-10.32.38-1024x500.png\" alt=\"\" class=\"wp-image-22224\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Screenshot-2025-09-17-at-10.32.38-1024x500.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Screenshot-2025-09-17-at-10.32.38-300x147.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Screenshot-2025-09-17-at-10.32.38-768x375.png 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Screenshot-2025-09-17-at-10.32.38-1536x750.png 1536w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/Screenshot-2025-09-17-at-10.32.38-2048x1000.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>La terapia CAR-T est\u00e1 siendo una revoluci\u00f3n en terapias de leucemias y linfomas, y tiene un extraordinario potencial para tumores s\u00f3lidos y otras patolog\u00edas. Emplea c\u00e9lulas del propio paciente modificadas gen\u00e9ticamente para expresar un receptor quim\u00e9rico que le permita reconocer y eliminar directamente las c\u00e9lulas tumorales. De entre todos los c\u00e1nceres, el de p\u00e1ncreas es uno de los m\u00e1s agresivos, siendo la mayor\u00eda de las terapias ineficaces, al igual que el g\u00e1strico, en sus estadios m\u00e1s avanzados y, por tanto, es necesario dise\u00f1ar nuevos abordajes terap\u00e9uticos.&nbsp;<\/p>\n\n\n\n<p>El objetivo del proyecto es desarrollar una inmunoterapia dirigida frente a c\u00e1nceres tanto g\u00e1stricos como pancre\u00e1ticos que sobre-expresan la prote\u00edna Claudina 18.2 en la membrana de las c\u00e9lulas tumorales. Para ello, se han obtenido anticuerpos espec\u00edficos contra la diana mediante la tecnolog\u00eda de hibridomas. Con esta tecnolog\u00eda, se han desarrollado hibridomas secretores de anticuerpos monoclonales dirigidos a la prote\u00edna diana y se ha validado en una l\u00ednea celular de c\u00e1ncer de p\u00e1ncreas su capacidad de reconocer la diana de manera espec\u00edfica. Adem\u00e1s, se han identificado las secuencias de la cadena pesada y ligera del anticuerpo obtenido, lo que permitir\u00e1 dise\u00f1ar un vector viral que sea pueda emplear para modificar gen\u00e9ticamente los linfocitos T del propio paciente en una terapia CAR-T espec\u00edfica.&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>Este proyecto ha sido desarrollado en la Universidad de Vigo en colaboraci\u00f3n con Galaria-Empresa P\u00fablica de Servicios Sanitarios y el Hospital Cl\u00ednic de Barcelona, habiendo contribuido todas ellas en una solicitud de una patente sobre los resultados de este proyecto.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-file alignwide\"><a id=\"wp-block-file--media-585da4b4-fe33-404b-a3fd-4b3b6ce09f34\" href=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/ALACARTA_AG.pdf\">Descargar ficha resultados<\/a><\/div>\n\n\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"3543\" height=\"506\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo.png\" alt=\"\" class=\"wp-image-2176\" style=\"width:211px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo.png 3543w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-300x43.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-1024x146.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-768x110.png 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-1536x219.png 1536w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/10\/Univ-Vigo-2048x292.png 2048w\" sizes=\"(max-width: 3543px) 100vw, 3543px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"225\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/galaria.png\" alt=\"\" class=\"wp-image-10727\" style=\"width:216px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/galaria.png 225w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/04\/galaria-150x150.png 150w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"317\" height=\"178\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/imagen-2.png\" alt=\"\" class=\"wp-image-17974\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/imagen-2.png 317w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/11\/imagen-2-300x168.png 300w\" sizes=\"(max-width: 317px) 100vw, 317px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 2 (LA2)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Dise\u00f1o de CAR-T acad\u00e9mico anti-claudina 18.2.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> immunoterapia, CAR-T, Tumores de p\u00e1ncreas y est\u00f3mago, anticuerpo monoclonal<\/p>\n","protected":false},"author":15,"featured_media":17962,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[245],"tags":[161,182,133],"class_list":["post-17966","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-ca","tag-analisis-de-datos-ca","tag-galicia-ca","tag-proyecto-colaborativo-ca"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/17966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/comments?post=17966"}],"version-history":[{"count":6,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/17966\/revisions"}],"predecessor-version":[{"id":22243,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/17966\/revisions\/22243"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media\/17962"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media?parent=17966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/categories?post=17966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/tags?post=17966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}