{"id":14764,"date":"2024-07-03T12:13:54","date_gmt":"2024-07-03T12:13:54","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=14764"},"modified":"2024-07-03T12:13:56","modified_gmt":"2024-07-03T12:13:56","slug":"screentech-palmitoscreen","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/ca\/screentech-palmitoscreen\/","title":{"rendered":"ScreenTech-PalmitoSCREEN"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"383\" height=\"394\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge4.png\" alt=\"\" class=\"wp-image-14758\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge4.png 383w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/Imatge4-292x300.png 292w\" sizes=\"(max-width: 383px) 100vw, 383px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Detecci\u00f3n de palmitoilaci\u00f3n de prote\u00ednas para atacar el c\u00e1ncer (PalmitoSCREEN)<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\">L\u00cdNEA DE ACTUACI\u00d3N 3: PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS DE INTERACCIONES F\u00c1RMACO-DIANA<br><br><strong>Palabras clave:<\/strong> c\u00e1ncer, palmitoilaci\u00f3n, cribado masivo<br><strong>Coordina: <\/strong>Universitat de Barcelona<br><strong>Participa:<\/strong> Instituto de Investigaci\u00f3n Biom\u00e9dica (IRB Barcelona)<br><strong>Persona de contacto: <\/strong>Miguel Mart\u00edn P\u00e9rez | martinperez@ub.edu<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>A pesar de los recientes avances en investigaci\u00f3n, la met\u00e1stasis sigue siendo responsable del 90% de las muertes relacionadas con el c\u00e1ncer. Si bien la resecci\u00f3n quir\u00fargica y la terapia adyuvante pueden curar los tumores localizados, una vez que las c\u00e9lulas tumorales hacen met\u00e1stasis, el c\u00e1ncer sigue siendo en gran medida incurable. Cada vez hay m\u00e1s pruebas que indican que los l\u00edpidos desempe\u00f1an un papel crucial en el proceso metast\u00e1sico al proporcionar energ\u00eda y componentes de membrana necesarios para la migraci\u00f3n y el crecimiento celular, y al desencadenar cascadas de se\u00f1alizaci\u00f3n espec\u00edficas que preparan a las c\u00e9lulas cancerosas para que entren en un programa metast\u00e1sico. Es importante destacar que el \u00e1cido palm\u00edtico promueve la met\u00e1stasis en muchos tumores, y que las c\u00e9lulas iniciadoras de met\u00e1stasis requieren una reprogramaci\u00f3n del metabolismo de los l\u00edpidos impulsada por una remodelaci\u00f3n epigen\u00e9tica. Tenemos evidencia de que los \u00e1cidos grasos no solo promueven la met\u00e1stasis proporcionando energ\u00eda a las c\u00e9lulas metast\u00e1sicas, sino tambi\u00e9n modulando la lipidaci\u00f3n de prote\u00ednas (espec\u00edficamente la palmitoilaci\u00f3n). Por lo tanto, atacar a esta maquinaria de se\u00f1alizaci\u00f3n de l\u00edpidos puede representar una soluci\u00f3n inexplorada para combatir la met\u00e1stasis. Sin embargo, hay poca informaci\u00f3n sobre la lipidaci\u00f3n de prote\u00ednas y su implicaci\u00f3n en la progresi\u00f3n del c\u00e1ncer, y no se dispone de inhibidores de grado cl\u00ednico contra este tipo de se\u00f1alizaci\u00f3n. Utilizando m\u00e9todos de cribado masivo similares a los desarrollados contra otros mediadores de se\u00f1alizaci\u00f3n lip\u00eddica, PalmitoSCREEN pretende identificar nuevas mol\u00e9culas capaces de inhibir la actividad de estas enzimas para tratar la met\u00e1stasis en modelos precl\u00ednicos, con el objetivo de acercarlas a la cl\u00ednica. Estos inhibidores tienen el potencial de convertirse en medicamentos de primera clase, lo que hace que esta propuesta sea un proyecto de alto riesgo, pero de gran beneficio, considerando el creciente n\u00famero de pacientes con c\u00e1ncer.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"305\" height=\"92\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/imagen-7.png\" alt=\"\" class=\"wp-image-14748\" style=\"width:259px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/imagen-7.png 305w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/imagen-7-300x90.png 300w\" sizes=\"(max-width: 305px) 100vw, 305px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"103\" height=\"195\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/07\/imagen-8.png\" alt=\"\" class=\"wp-image-14753\" style=\"width:87px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Detecci\u00f3n de palmitoilaci\u00f3n de prote\u00ednas para atacar el c\u00e1ncer (PalmitoSCREEN).<\/p>\n<p><&#038;nbsp><br \/>\n<strong>Palabras clave:<\/strong> c\u00e1ncer, palmitoilaci\u00f3n, cribado masivo.<\/p>\n","protected":false},"author":15,"featured_media":14760,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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