{"id":10491,"date":"2024-03-26T16:13:18","date_gmt":"2024-03-26T16:13:18","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/nanothera-pet\/"},"modified":"2025-06-16T13:03:36","modified_gmt":"2025-06-16T13:03:36","slug":"nanothera-pet","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/ca\/nanothera-pet\/","title":{"rendered":"NANOTHERA-PET"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image alignright size-full is-resized has-custom-border\"><img decoding=\"async\" width=\"207\" height=\"118\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/nanoteraped.png\" alt=\"\" class=\"wp-image-10386\" style=\"border-radius:7px;width:254px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Un Nuevo Enfoque Nanoteranostico Para El Glioblastoma Basado En Nanoportadores E Inmuno-Pet Radiofarmac\u00e9uticos<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 5:<\/strong> DESARROLLO DE NANOF\u00c1RMACOS, BIODISTRIBUCI\u00d3N, TOXICIDAD Y ACCIONES TERAP\u00c9UTICAS EN MODELOS DE PATOLOG\u00cdA.<br><br><strong>Palabras clave:<\/strong> Imagen Pet; Nanotecnolog\u00eda; Glioblastoma; Teragnosis Pet Imaging; Nanotechnology; Glioblastoma; Theragnosis<br><strong>Coordina:<\/strong> Universidade de Santiago de Compostela<br><strong>Participa:<\/strong> Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (Galicia); Universidad de Vigo; Vall d\u2019Hebron Institut d&#8217;Oncolog\u00eda (Catalu\u00f1a); Vall d&#8217;Hebron Institut de Recerca (Catalu\u00f1a)<br><strong>Persona de contacto:<\/strong> Pablo Aguiar y Maria J. Alonso (pablo.aguiar@usc.es \/ mariaj.alonso@usc.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>Los radiof\u00e1rmacos se pueden utilizar para obtener im\u00e1genes no invasivas de la expresi\u00f3n de las diferentes dianas terap\u00e9uticas en c\u00e1ncer utilizando anticuerpos monoclonales radiomarcados con radiois\u00f3topos PET como 89Zr o 68Ga (Inmuno-PET). Adem\u00e1s, estos radiof\u00e1rmacos ofrecen la posibilidad de crear su versi\u00f3n teran\u00f3stica, utilizando radionucleidos emisores beta- (177Lu) o emisores alfa (Ac-225, 211At, 227Th\u2026), que pueden usarse para administrar una dosis de radiaci\u00f3n selectiva y reducir los efectos secundarios en los tejidos sanos. Esta emergente alternativa ha tenido un enorme \u00e9xito en muchos tipos de c\u00e1ncer, como el mieloma, el c\u00e1ncer de pulm\u00f3n, el c\u00e1ncer de mama, el c\u00e1ncer urol\u00f3gico, el carcinoma hepatocelular o los tumores de cabeza y cuello. Sin embargo, se ha encontrado con desaf\u00edos importantes en algunas situaciones espec\u00edficas donde existen barreras fisiol\u00f3gicas que pueden impedir la llegada de mol\u00e9culas grandes como los anticuerpos. Este es el caso de los tumores cerebrales, donde los anticuerpos encuentran dificultades para su transporte a trav\u00e9s de la BHE y su posterior difusi\u00f3n a trav\u00e9s del tejido cerebral.<\/p>\n\n\n\n<p>Nuestra idea es abordar este desaf\u00edo aprovechando los recientes hallazgos en el desarrollo de nanoportadores funcionalizados para superar la BHE. El objetivo de este proyecto es dise\u00f1ar, desarrollar y validar radiof\u00e1rmacos Inmuno-PET nanoencapsulados para el diagn\u00f3stico y el tratamiento basado en radion\u00faclidos de tumores cerebrales. Nuestro proyecto desarrollar\u00e1 una estrategia para medir la farmacocin\u00e9tica y la biodistribuci\u00f3n de anticuerpos dirigidos a diferentes prote\u00ednas EGFRVIII del glioblastoma multiforme (GBM), el tumor cerebral m\u00e1s com\u00fan y agresivo. Posteriormente se aplicar\u00e1n tratamientos basados en radion\u00faclidos utilizando 177Lu. EL plan de trabajo se inicia con un evaluaci\u00f3n de una serie de nanoportadores para determinar su eficacia para cruzar la BHE. En segundo lugar, se probar\u00e1 la capacidad de los nanoportadores seleccionados para medir la expresi\u00f3n in vivo de los receptores EGFRVIII. En tercer lugar, los candidatos m\u00e1s prometedores tambi\u00e9n ser\u00e1n radiomarcados con 177Lu para administrar una dosis terap\u00e9utica de radiaci\u00f3n selectiva a las c\u00e9lulas tumorales.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto NANOTHERA-PET - Un nuevo enfoque nanoteranostico para el Glioblastoma\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/0ga_ApRpUQ0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"779\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1.png\" alt=\"\" class=\"wp-image-10044\" style=\"width:165px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1.png 1200w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-300x195.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-1024x665.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-768x499.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1100\" height=\"800\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1.png\" alt=\"\" class=\"wp-image-9626\" style=\"width:172px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1.png 1100w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1-300x218.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1-1024x745.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1-768x559.png 768w\" sizes=\"(max-width: 1100px) 100vw, 1100px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"990\" height=\"565\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1.png\" alt=\"\" class=\"wp-image-1392\" style=\"width:171px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1.png 990w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1-300x171.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/vall-dhebron_2-1-768x438.png 768w\" sizes=\"(max-width: 990px) 100vw, 990px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"506\" height=\"179\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-26-at-17-11-39-vhio-logo-Buscar-con-Google.png\" alt=\"\" class=\"wp-image-10394\" style=\"width:201px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-26-at-17-11-39-vhio-logo-Buscar-con-Google.png 506w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Screenshot-2024-03-26-at-17-11-39-vhio-logo-Buscar-con-Google-300x106.png 300w\" sizes=\"(max-width: 506px) 100vw, 506px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 5 (LA5)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Un Nuevo Enfoque Nanoteranostico Para El Glioblastoma Basado En Nanoportadores E Inmuno-Pet Radiofarmac\u00e9uticos.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> Imagen Pet; Nanotecnolog\u00eda; Glioblastoma; Teragnosis Pet Imaging; Nanotechnology; Glioblastoma; Theragnosis. <\/p>\n","protected":false},"author":15,"featured_media":10388,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[245],"tags":[182,205,133],"class_list":["post-10491","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-ca","tag-galicia-ca","tag-nanofarmacos-ca","tag-proyecto-colaborativo-ca"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/10491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/comments?post=10491"}],"version-history":[{"count":3,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/10491\/revisions"}],"predecessor-version":[{"id":20088,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/10491\/revisions\/20088"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media\/10388"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media?parent=10491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/categories?post=10491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/tags?post=10491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}