{"id":10480,"date":"2024-03-26T15:49:07","date_gmt":"2024-03-26T15:49:07","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/nanoarpah\/"},"modified":"2025-06-16T13:02:08","modified_gmt":"2025-06-16T13:02:08","slug":"nanoarpah","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/ca\/nanoarpah\/","title":{"rendered":"NanoARPAH"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image alignright size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"837\" height=\"610\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Picture2.jpg\" alt=\"\" class=\"wp-image-10378\" style=\"border-radius:7px;width:254px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Picture2.jpg 837w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Picture2-300x219.jpg 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Picture2-768x560.jpg 768w\" sizes=\"(max-width: 837px) 100vw, 837px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<h2 class=\"wp-block-heading\">Nanof\u00e1rmacos de ARNm y p\u00e9ptidos anfif\u00edlicos para s\u00edndrome de Hurler<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 5:<\/strong> DESARROLLO DE NANOF\u00c1RMACOS, BIODISTRIBUCI\u00d3N, TOXICIDAD Y ACCIONES TERAP\u00c9UTICAS EN MODELOS DE PATOLOG\u00cdA.<br><br><strong>Palabras clave:<\/strong> S\u00edndrome de Hurler; terapias basadas en ARNm; nanoveh\u00edculos<br><strong>Coordina:<\/strong> Fundaci\u00f3n Kaertor<br><strong>Participa:<\/strong> Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (Galicia); Universidad de Santiago de Compostela (Galicia); Xunta de Galicia (Galicia).<br><strong>Persona de contacto:<\/strong> Javier Montenegro Garc\u00eda (javier.montenegro@usc.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<p>El s\u00edndrome de Hurler, tambi\u00e9n conocido como mucopolisacaridosis tipo I (MPS I), es una enfermedad rara debida a la deficiencia o ausencia de la enzima \u03b1-L-iduronidasa, lo que provoca afectaciones multisist\u00e9micas. Este tipo de enfermedades suelen aparecer en los primeros a\u00f1os de vida.<\/p>\n\n\n\n<p>Existe un tratamiento de reemplazo enzim\u00e1tico, administrado por perfusi\u00f3n semanalmente (Aldurazyme\u00ae). Este tratamiento tiene las carencias de no atravesar la barrera hematoencef\u00e1lica, no alcanzar tejidos poco vascularizados y tiene una actividad inmunog\u00e9nica que provoca la generaci\u00f3n de anticuerpos. Existe la necesidad de desarrollar nuevas terapias que solucionen los problemas actuales y mejoren la calidad de vida.<\/p>\n\n\n\n<p>Las terapias basadas en ARNm se han posicionado como una alternativa muy atractiva para el desarrollo de nuevos f\u00e1rmacos como vacunas, inmunoterapias o para terapias de reemplazo. Presentan ventajas significativas frente al desarrollo de prote\u00ednas recombinantes, ya que el ARNm puede ser dise\u00f1ado y producido de manera r\u00e1pida, y la prote\u00edna se produce en la propia c\u00e9lula del paciente. No obstante, los ARNm terap\u00e9uticos requieren de veh\u00edculos que los protejan hasta su sitio de acci\u00f3n, el citosol celular, para ser efectivos y seguros.<\/p>\n\n\n\n<p>Este proyecto propone la utilizaci\u00f3n de una novedosa tecnolog\u00eda de entrega de ARNm desarrollada por el grupo del Dr. Javier Montenegro en la USC para llevar a cabo el transporte de un ARNm terap\u00e9utico codificador de la prote\u00edna \u03b1-iduronidasa. Tras la s\u00edntesis, caracterizaci\u00f3n y formulaci\u00f3n de estos nanoveh\u00edculos con ARNm, se llevar\u00e1 a cabo la evaluaci\u00f3n precl\u00ednica (in vitro e in vivo) por parte del grupo liderado por la Dra. M\u00ba Luz Couce y el Dr. Francisco J. Otero Espinar, integrados en el IDIS y en la USC, quienes cuentan con amplia experiencia en metabolopat\u00edas, en el desarrollo y evaluaci\u00f3n de nuevos tratamientos y acceso a modelos patol\u00f3gicos relevantes para el desarrollo de esta nueva terapia.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto NanoARPAH - Nanof\u00e1rmacos de ARNm y p\u00e9ptidos anfif\u00edlicos para s\u00edndrome de Hurler\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/9z-UtXDroms?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"186\" height=\"71\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2022\/06\/kaertor.png\" alt=\"\" class=\"wp-image-673\" style=\"width:165px;height:auto\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1100\" height=\"800\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1.png\" alt=\"\" class=\"wp-image-9626\" style=\"width:172px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1.png 1100w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1-300x218.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1-1024x745.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_IDIS_2020-1-768x559.png 768w\" sizes=\"(max-width: 1100px) 100vw, 1100px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"779\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1.png\" alt=\"\" class=\"wp-image-10044\" style=\"width:171px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1.png 1200w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-300x195.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-1024x665.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-768x499.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"385\" height=\"110\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/xunta.png\" alt=\"\" class=\"wp-image-10372\" style=\"width:201px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/xunta.png 385w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/xunta-300x86.png 300w\" sizes=\"(max-width: 385px) 100vw, 385px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 5 (LA5)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Nanof\u00e1rmacos de ARNm y p\u00e9ptidos anfif\u00edlicos para s\u00edndrome de Hurler.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> S\u00edndrome de Hurler; terapias basadas en ARNm; nanoveh\u00edculos.<\/p>\n","protected":false},"author":15,"featured_media":10380,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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