{"id":10065,"date":"2024-03-22T11:56:47","date_gmt":"2024-03-22T11:56:47","guid":{"rendered":"https:\/\/planescomplementariossalud.es\/?p=10065"},"modified":"2025-06-16T13:17:57","modified_gmt":"2025-06-16T13:17:57","slug":"nidoa","status":"publish","type":"post","link":"https:\/\/planescomplementariossalud.es\/ca\/nidoa\/","title":{"rendered":"NiDOA"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:300px\">\n<figure class=\"wp-block-image size-full is-resized has-custom-border\"><img fetchpriority=\"high\" decoding=\"async\" width=\"522\" height=\"534\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-115743.png\" alt=\"\" class=\"wp-image-10029\" style=\"border-radius:7px;width:298px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-115743.png 522w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Captura-de-pantalla-2024-03-22-115743-293x300.png 293w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-ast-global-color-6-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:10px;padding-bottom:10px;padding-left:10px\">\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Descubrimiento de nuevos inhibidores de DPP4 para el tratamiento de la osteoartritis.<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:2px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-ast-global-color-6-background-color has-background\"><strong>LINEA DE ACTUACI\u00d3N 3: <\/strong>PLATAFORMA DE CRIBADO DE F\u00c1RMACOS Y AN\u00c1LISIS INTERACCIONES F\u00c1RMACO-DIANA<br>L\u00ednea de Actuaci\u00f3n Complementaria 4: Desarrollo de modelos biol\u00f3gicos para cribado y estudio de la actividad de mol\u00e9culas terap\u00e9uticas.<br><br><strong>Palabras clave:<\/strong> Dipeptidil peptidasa; Cribado de f\u00e1rmacos; Fucoidanos; Artrosis; Diabetes tipo 2.<br><strong>Coordina:<\/strong> Fundaci\u00f3n Profesor Novoa Santos<br><strong>Participa:<\/strong> Universidade da Coru\u00f1a (Galicia), Universidade de Santiago de Compostela (Galicia), Universida de Vigo (Galicia), CICbioGUNE (Pa\u00eds Vasco)<br><strong>Persona de contacto:<\/strong> Valentina Calamia (valentina.calamia@sergas.es); Carlos Vaamonde Garc\u00eda (carlos.vaamonde.garcia@sergas.es)<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:23px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-ast-global-color-4-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px\">\n<figure class=\"wp-block-video\"><\/figure>\n\n\n\n<p>Dipeptidil peptidasa (DPP4), tambi\u00e9n conocida como CD26, es una serina proteasa que escinde una variedad de sustratos, incluidas citoquinas, factores de crecimiento e incretinas; puede existir tanto anclada a membrana (mDPP4) como en forma soluble (sDPP4). La DPP4 ya se ha estudiado ampliamente en la fisiopatolog\u00eda de la diabetes tipo 2 (DM2), y los inhibidores de la DPP4 se emplean actualmente como f\u00e1rmacos antidiab\u00e9ticos eficaces y seguros (familia de las gliptinas).<\/p>\n\n\n\n<p>Sin embargo, investigaciones actuales indican que DPP4 posee funciones metab\u00f3licas m\u00e1s amplias que van m\u00e1s all\u00e1 de la regulaci\u00f3n de la glucosa en sangre. La actividad plasm\u00e1tica de sDPP4 aumenta en la obesidad y varios estudios han propuesto que sDPP4 se libera del tejido adiposo como una adipocina proinflamatoria que vincula la resistencia a la insulina con una inflamaci\u00f3n de bajo grado. Adem\u00e1s, los niveles de esta prote\u00edna tambi\u00e9n se encuentran aumentados en el liquido sinovial de pacientes que sufren artrosis (OA) de rodilla. Dada la asociaci\u00f3n existente entre artrosis, obesidad (en una poblaci\u00f3n cada vez con mayor sobrepeso) y diabetes (con una mayor prevalencia de OA en estos pacientes), planteamos la hip\u00f3tesis de una nueva oportunidad terap\u00e9utica para los pacientes que sufren esta condici\u00f3n debilitante.<\/p>\n\n\n\n<p>El objetivo del presente proyecto es evaluar el potencial de un conjunto de compuestos, incluidos los fucoidanos (biomol\u00e9culas aisladas de algas pardas), como nuevos inhibidores de DPP4 en un modelo in vitro de OA.<\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"ast-oembed-container \" style=\"height: 100%;\"><iframe title=\"Proyecto NIDOA- Descubrimiento de nuevos inhibidores de DPP4 para el tratamiento de la osteoartritis\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/PlsV824RrJw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">COORDINA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\">PARTICIPA:<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-text-align-center\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Fundacion-Profesor-Novoa-Santos_sin-fondo-1-1024x574.png\" alt=\"\" class=\"wp-image-10034\" style=\"width:185px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Fundacion-Profesor-Novoa-Santos_sin-fondo-1-1024x574.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Fundacion-Profesor-Novoa-Santos_sin-fondo-1-300x168.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Fundacion-Profesor-Novoa-Santos_sin-fondo-1-768x431.png 768w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Fundacion-Profesor-Novoa-Santos_sin-fondo-1.png 1189w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image alignright size-full is-resized\"><img decoding=\"async\" width=\"1200\" height=\"155\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/P_Entidad_900102373508234373_1099934327828_1200_1280_U_c332bb31bcf94d39a8e7b7b71c36ff6.png\" alt=\"\" class=\"wp-image-10039\" style=\"width:233px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/P_Entidad_900102373508234373_1099934327828_1200_1280_U_c332bb31bcf94d39a8e7b7b71c36ff6.png 1200w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/P_Entidad_900102373508234373_1099934327828_1200_1280_U_c332bb31bcf94d39a8e7b7b71c36ff6-300x39.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/P_Entidad_900102373508234373_1099934327828_1200_1280_U_c332bb31bcf94d39a8e7b7b71c36ff6-1024x132.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/P_Entidad_900102373508234373_1099934327828_1200_1280_U_c332bb31bcf94d39a8e7b7b71c36ff6-768x99.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"779\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1.png\" alt=\"\" class=\"wp-image-10044\" style=\"width:143px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1.png 1200w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-300x195.png 300w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-1024x665.png 1024w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotype_of_Universidade_de_Santiago_de_Compostela.svg-1-768x499.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"405\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotipo_Universidade_de_Vigo-edited.jpg\" alt=\"\" class=\"wp-image-10054\" style=\"width:151px;height:auto\" srcset=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotipo_Universidade_de_Vigo-edited.jpg 720w, https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/Logotipo_Universidade_de_Vigo-edited-300x169.jpg 300w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"232\" height=\"80\" src=\"https:\/\/planescomplementariossalud.es\/wp-content\/uploads\/2024\/03\/logo_grande.png\" alt=\"\" class=\"wp-image-10059\" style=\"width:155px;height:auto\"\/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-ast-global-color-6-color has-alpha-channel-opacity has-ast-global-color-6-background-color has-background\"\/>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p><i>L\u00ednea de actuaci\u00f3n 3 (LA3)<\/i><\/p>\n<p><&#038;nbsp><br \/>\n<\/p>\n<p>Descubrimiento de nuevos inhibidores de DPP4 para el tratamiento de la osteoartritis.<\/p>\n<p><\u00a0><br \/>\n<strong>Palabras clave:<\/strong> Dipeptidil peptidasa; Cribado de f\u00e1rmacos; Fucoidanos; Artrosis; Diabetes tipo 2.<\/p>\n","protected":false},"author":3,"featured_media":10031,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[245],"tags":[86,182,133],"class_list":["post-10065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyecto-ca","tag-cribado-de-farmacos-ca","tag-galicia-ca","tag-proyecto-colaborativo-ca"],"_links":{"self":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/10065","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/comments?post=10065"}],"version-history":[{"count":3,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/10065\/revisions"}],"predecessor-version":[{"id":20139,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/posts\/10065\/revisions\/20139"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media\/10031"}],"wp:attachment":[{"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/media?parent=10065"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/categories?post=10065"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/planescomplementariossalud.es\/ca\/wp-json\/wp\/v2\/tags?post=10065"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}